Mechanisms involved in the renal responses to intravenous and renal artery infusions of noradrenaline in conscious dogs Anderson, W. P., Korner, P. I. and Selig, S. E. 1981, Mechanisms involved in the renal responses to intravenous and renal artery infusions of noradrenaline in conscious dogs, Journal of physiology, vol. 321, pp. 21-30. Attached Files Name Description MIMEType Size Downloads selig-mechanismsinvolved-1981.pdf Published version application/pdf 1.15MB 205 Title Mechanisms involved in the renal responses to intravenous and renal artery infusions of noradrenaline in conscious dogs Author(s) Anderson, W. P. Korner, P. I. Selig, S. E. orcid.org/0000-0003-4159-5111 Journal name Journal of physiology Volume number 321 Start page 21 End page 30 Publisher Cambridge University Press Place of publication London, England Publication date 1981-12 ISSN 0022-3751 1469-7793 Summary 1. The renal haemodynamic and glomerular filtration rate (G.F.R.) responses to intravenous and intrarenal infusions of noradrenaline were studied in conscious dogs, either with or without prior blockade of angiotensin II formation with teprotide. 2. Infusion noradrenaline by either route resulted in dose-related rises in plasma renin activity. 3. Pretreatment with teprotide reduced the rise in mean arterial pressure and abolished the rise in G.F.R. seen during intravenous infusions of noradrenaline (0.1, 0.2 and 0.4 microgram/kg . min). Noradrenaline also reduced filtration fraction more after teprotide pretreatment. 4. Renal blood flow rose and renal vascular resistance fell in response to I.V. noradrenaline infusions. This renal vasodilatation was unaffected by pretreatment of the dogs with teprotide, indomethacin or DL-propranolol. However after pentolinium pretreatment, I.V. noradrenaline infusion caused a dose-related renal vasoconstriction. 5. Infusion of noradrenaline into the renal artery (0.02, 0.05 and 0.1 microgram/kg . min) resulted in rises in mean arterial pressure and G.F.R. which were abolished by teprotide pretreatment. Filtration fraction rose when noradrenaline was administered alone but fell when it was infused after teprotide treatment. 6. Thus angiotensin II formed as the result of increased renin release acted to maintain G.F.R. and filtration fraction during noradrenaline infusion. In addition, I.V. noradrenaline infusions in conscious dogs caused reflex vasodilatation of the renal vasculature. Notes Reproduced with the kind permission of the copyright owner. Language eng Field of Research 119999 Medical and Health Sciences not elsewhere classified Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1.1 Refereed article in a scholarly journal Copyright notice ©1981, Cambridge University Press Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30033411 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Open Access Collection Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Wed, 16 Mar 2011, 14:59:49 EST Wed, 04 May 2011, 10:20:01 EST Wed, 04 May 2011, 10:21:12 EST Tue, 02 Aug 2011, 11:39:25 EST Mon, 16 Jun 2014, 17:35:04 EST Tue, 05 Dec 2017, 10:48:15 EST Fri, 07 Sep 2018, 15:19:54 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 0 times in Scopus Search Google Scholar Access Statistics: 406 Abstract Views, 205 File Downloads  -  Detailed Statistics Created: Wed, 16 Mar 2011, 14:59:49 EST