BDNF, metabolic risk factors, and resistance training in middle-aged individuals

Levinger, Itamar, Goodman, Craig, Matthews, Vance, Hare, David L., Jerums, George, Garnham, Andrew and Selig, Steve 2008, BDNF, metabolic risk factors, and resistance training in middle-aged individuals, Medicine and science in sports and exercise, vol. 40, no. 3, pp. 535-541, doi: 10.1249/MSS.0b013e31815dd057.

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Title BDNF, metabolic risk factors, and resistance training in middle-aged individuals
Author(s) Levinger, Itamar
Goodman, Craig
Matthews, Vance
Hare, David L.
Jerums, George
Garnham, Andrew
Selig, SteveORCID iD for Selig, Steve
Journal name Medicine and science in sports and exercise
Volume number 40
Issue number 3
Start page 535
End page 541
Total pages 7
Publisher Lippincott Williams and Wilkins
Place of publication Philadelphia, Pa.
Publication date 2008-03
ISSN 0195-9131
Keyword(s) cluster of risk factors
brain-derived neurotrophic factor
exercise rehabilitation
Summary Introduction and Purpose: Brain-derived neurotrophic factor (BDNF) and physical inactivity contribute to the development of the metabolic syndrome (MetS). There appears to be an association between BDNF and risk factors for MetS, and the effects of resistance training (RT) on BDNF and metabolic risk in middle-aged individuals with high and low numbers of metabolic risk factors (HiMF and LoMF, respectively) are unclear and are the focus of this research.

Methods: Forty-nine men (N = 25) and women (N = 24) aged 50.9 ± 6.2 yr were randomized to four groups, HiMF training (HiMFT), HiMF control (HiMFC), LoMF training (LoMFT), and LoMF control (LoMFC). Before and after 10 wk of RT, participants underwent tests for muscle strength and anthropometry, and a fasting blood sample was taken. Data were analyzed using Spearman correlations and repeated-measures ANOVA.

Results: BDNF was positively correlated with plasma triglycerides, glucose, HbA1C, and insulin resistance. BDNF was elevated in HiMF compared with LoMF (904.9 ± 270.6 vs 709.6 ± 239.8 respectively, P = 0.01). Training increased muscle strength and lean body mass but had no effect on BDNF levels or any examined risk factors.

Conclusion: BDNF levels correlated with risk factors for MetS and were elevated in individuals with HiMF. RT had no effect on BDNF levels or other risk factors for MetS. As RT has an effect on muscle strength and lean body mass, it should be added to other nonpharmacological interventions for middle-aged individuals with HiMF such as aerobic and/or diet.
Language eng
DOI 10.1249/MSS.0b013e31815dd057
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2008, American College of Sports Medicine
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Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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