Reduced exercise tolerance in CHF may be related to factors other than impaired skeletal muscle oxidative capacity

Williams, Andrew D., Selig, Steve, Hare, David L., Hayes, Alan, Krum, Henry, Patterson, Jeremy, Geerling, Ralph H., Toia, Deidre and Carey, Michael F. 2004, Reduced exercise tolerance in CHF may be related to factors other than impaired skeletal muscle oxidative capacity, Journal of cardiac failure, vol. 10, no. 2, pp. 141-148, doi: 10.1016/j.cardfail.2003.09.004.

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Title Reduced exercise tolerance in CHF may be related to factors other than impaired skeletal muscle oxidative capacity
Author(s) Williams, Andrew D.
Selig, SteveORCID iD for Selig, Steve
Hare, David L.
Hayes, Alan
Krum, Henry
Patterson, Jeremy
Geerling, Ralph H.
Toia, Deidre
Carey, Michael F.
Journal name Journal of cardiac failure
Volume number 10
Issue number 2
Start page 141
End page 148
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2004-04
ISSN 1071-9164
Keyword(s) exercise capacity
skeletal muscle
Summary Background : We sought to determine whether skeletal muscle oxidative capacity, fiber type proportions, and fiber size, capillary density or muscle mass might explain the impaired exercise tolerance in chronic heart failure (CHF). Previous studies are equivocal regarding the maladaptations that occur in the skeletal muscle of patients with CHF and their role in the observed exercise intolerance.

Methods and results :
Total body O2 uptake (VO2peak) was determined in 14 CHF patients and 8 healthy sedentary similar-age controls. Muscle samples were analyzed for mitochondrial adenosine triphosphate (ATP) production rate (MAPR), oxidative and glycolytic enzyme activity, fiber size and type, and capillary density. CHF patients demonstrated a lower VO2peak (15.1±1.1 versus 28.1±2.3 mL·kg−1·min−1, P<.001) and capillary to fiber ratio (1.09±0.05 versus 1.40±0.04; P<.001) when compared with controls. However, there was no difference in capillary density (capillaries per square millimeter) across any of the fiber types. Measurements of MAPR and oxidative enzyme activity suggested no difference in muscle oxidative capacity between the groups.

Conclusions : Neither reductions in muscle oxidative capacity nor capillary density appear to be the cause of exercise limitation in this cohort of patients. Therefore, we hypothesize that the low VO2peak observed in CHF patients may be the result of fiber atrophy and possibly impaired activation of oxidative phosphorylation.
Language eng
DOI 10.1016/j.cardfail.2003.09.004
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2004, Elsevier Inc
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Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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