Antiamnesic effect of stevioside in scopolamine-treated rats

Sharma, Deepika, Puri, Munish, Tiwary, Ashok K., Singh, Nirmal and Jaggi, Amteshwar Singh 2010, Antiamnesic effect of stevioside in scopolamine-treated rats, Indian journal of pharmacology, vol. 42, no. 3, May-June, pp. 164-167.

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Title Antiamnesic effect of stevioside in scopolamine-treated rats
Author(s) Sharma, Deepika
Puri, MunishORCID iD for Puri, Munish
Tiwary, Ashok K.
Singh, Nirmal
Jaggi, Amteshwar Singh
Journal name Indian journal of pharmacology
Volume number 42
Issue number 3
Season May-June
Start page 164
End page 167
Total pages 4
Publisher Medknow Publications and Media
Place of publication Mumbai, India
Publication date 2010-06
ISSN 0253-7613
Keyword(s) memory
Morris water-maze
Summary The present study was undertaken to explore the potential of Stevioside in memory dysfunction of rats. Memory impairment was produced by Scopolamine (0.5 mg/kg, i.p.) in animals. Morris water-maze test was employed to assess learning and memory. Brain acetylcholinestrase enzyme (AChE) activity was measured to assess central cholinergic activity. The levels of brain thio-barbituric acid reactive species (TBARS) and reduced glutathione (GSH) were estimated to assess degree of oxidative stress. Scopolamine administration induced significant impairment of learning and memory in rats as indicated by marked decrease in Morris water-maze performance. Scopolamine administration also produced a significant enhancement of brain AChE activity and brain oxidative stress (increase in TBARS & decrease in GSH) levels. Pretreatment of Stevioside (250mg/kg dose orally) significantly reversed Scopolamine induced learning & memory deficits along with attenuation of Scopolamine induced rise in brain AChE activity and brain oxidative stress levels. It may be concluded that Stevioside exerts memory preservative effect in cognitive deficits of rats possibly through its multiple actions.
Language eng
Field of Research 090803 Food Nutritional Balance
Socio Economic Objective 920411 Nutrition
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2010
Copyright notice ©2010, Medknow Publications Pvt. Ltd.
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Created: Wed, 23 Mar 2011, 10:55:08 EST by Munish Puri

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