Marsupial milk : identifying signals for regulating mammary function and development of the young

Sharp, Julie A., Lefevre, Christophe, Kwek, Joly, Topcic, Denijal, Buscara, Laurine, Pooley, Cate, de Iongh, Robb, Familari, Mary and Nicholas, Kevin R. 2010, Marsupial milk : identifying signals for regulating mammary function and development of the young. In Deakin, Janine E., Waters, Paul D. and Marshall Graves, Jennifer A. (ed), Marsupial genetics and genomics, Springer, Dordrecht, The Netherlands, pp.317-334, doi: 10.1007/978-90-481-9023-2_15.

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Title Marsupial milk : identifying signals for regulating mammary function and development of the young
Author(s) Sharp, Julie A.ORCID iD for Sharp, Julie A.
Lefevre, Christophe
Kwek, Joly
Topcic, Denijal
Buscara, Laurine
Pooley, Cate
de Iongh, Robb
Familari, Mary
Nicholas, Kevin R.
Title of book Marsupial genetics and genomics
Editor(s) Deakin, Janine E.
Waters, Paul D.
Marshall Graves, Jennifer A.
Publication date 2010
Chapter number 15
Total chapters 23
Start page 317
End page 334
Total pages 18
Publisher Springer
Place of Publication Dordrecht, The Netherlands
Keyword(s) milk
Summary The role of milk in providing nutrition for the young is well established. However, it is becoming apparent that milk has a more comprehensive role in programming and regulating growth and development of the suckled young, and an autocrine impact on the mammary gland so that it functions appropriately during the lactation cycle. This central role of milk is best studied in animal models, such as marsupials that have evolved a different lactation strategy to eutherians and allow researchers to more easily identify regulatory mechanisms that are not as readily apparent in eutherian species. For example, the tammar wallaby (Macropus eugenii) has evolved with a unique reproductive strategy of a short gestation, birth of an altricial young and a relatively long lactation during which the mother progressively changes the composition of the major, and many of the minor components of milk. Thus, in contrast to eutherians, there is a far greater investment in development of the young during lactation and it is likely that many of the signals that regulate development of eutherian embryos in utero are delivered by the milk. This requires the co-ordinated development and function of the mammary gland. Inappropriate timing of these signalling events in mammals may result in either limited or abnormal development of the young, and potentially a higher incidence of mature onset disease. The tammar is emerging as an attractive model to better understand the role of milk factors in these processes.
ISBN 9048190223
Language eng
DOI 10.1007/978-90-481-9023-2_15
Field of Research 111404 Reproduction
Socio Economic Objective 830507 Unprocessed or Minimally Processed Milk
HERDC Research category B1 Book chapter
HERDC collection year 2010
Copyright notice ©2010, Springer
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