Inferring minimal feasible metabolic networks of Escherichia coli

Jiang, Da, Zhou, Shuigeng, Liu, Hui and Chen, Yi-Ping Phoebe 2010, Inferring minimal feasible metabolic networks of Escherichia coli, Applied biochemistry and biotechnology, vol. 160, no. 1, pp. 222-231, doi: 10.1007/s12010-009-8572-5.

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Title Inferring minimal feasible metabolic networks of Escherichia coli
Formatted title Inferring minimal feasible metabolic networks of Escherichia coli
Author(s) Jiang, Da
Zhou, Shuigeng
Liu, Hui
Chen, Yi-Ping Phoebe
Journal name Applied biochemistry and biotechnology
Volume number 160
Issue number 1
Start page 222
End page 231
Publisher Humana Press
Place of publication Totowa, N. J.
Publication date 2010
ISSN 0273-2289
Keyword(s) metabolic networks
minimal reaction sets
structure analysis
Summary Since the organism contains many redundant reactions, the minimal feasible metabolic network that contains the basic growth function is not the collection of reactions that associate the essential genes. To identify minimal metabolic reaction set is a challenging work in theoretical approach. A new method is presented here to identify the smallest required reaction set of growth-sustaining metabolic networks. The content and number of the minimal reactions for growth are variable in different random processes. Though the different carbon sources also vary the content of the reactions in the minimal metabolic networks, most essential reactions locate in the same metabolic subsystems, such as cofactor and prosthetic group biosynthesis, cell envelope biosynthesis, and membrane lipid metabolism.
Language eng
DOI 10.1007/s12010-009-8572-5
Field of Research 080301 Bioinformatics Software
Socio Economic Objective 890299 Computer Software and Services not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2010
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