Muscle determinants of bone mass, geometry and strength in prepubertal girls

Daly, Robin M., Stenevi-Lundgren, Susanna, Linden, Christian and Karlsson, Magnus K. 2008, Muscle determinants of bone mass, geometry and strength in prepubertal girls, Medicine and Science in Sports and Exercise, vol. 40, no. 6, pp. 1135-1141, doi: 10.1249/MSS.0b013e318169bb8d.

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Title Muscle determinants of bone mass, geometry and strength in prepubertal girls
Author(s) Daly, Robin M.ORCID iD for Daly, Robin M.
Stenevi-Lundgren, Susanna
Linden, Christian
Karlsson, Magnus K.
Journal name Medicine and Science in Sports and Exercise
Volume number 40
Issue number 6
Start page 1135
End page 1141
Total pages 7
Publisher Lippincott Williams & Wilkins
Place of publication Philadelphia, Pa.
Publication date 2008-06
ISSN 0195-9131
Summary Purpose: The aim of this study was to compare the relative contribution of peak muscle force (isokinetic peak torque) with surrogate estimates of muscle force, including leg lean tissue mass (LTM) and vertical jump height (VJH), on bone mass, geometry and strength in healthy prepubertal girls (n = 103).

Total leg and FN BMC and leg LTM were measured by DXA; the hip strength analysis program was used to assess FN diameter, cross-sectional area (CSA) and section modulus (Z). Isokinetic peak torque of the knee extensors and flexors (60°·s-1) were used as direct measures of peak muscle force. VJH was measured as an estimate of neuromuscular function. Total leg length or femoral length was used as a surrogate measure of moment arm length.

All estimates of muscle function, except VJH, were positively associated with leg BMC (r = 0.72 - 0.90) and FN BMC, geometry and strength (r = 0.35-0.65) (all, P < 0.001). Multiple linear regression analyses revealed that leg LTM and isokinetic peak torque were independently and equally predictive of leg BMC and FN BMC, bone geometry and strength, explaining 8 to 28% of the variance in each of the bone traits after accounting for moment arm length. When isokinetic peak torque was corrected for both leg LTM and moment arm length, it remained an independent predictor of BMC, CSA and Z, but only accounted for an additional 2 to 5% of the variance.

Conclusion: These data suggest that DXA-derived leg LTM can be used as a reasonable surrogate for isokinetic peak muscle forces when assessing bone strength in relation to muscular function in healthy pre-pubertal girls.
Language eng
DOI 10.1249/MSS.0b013e318169bb8d
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Grant ID NHMRC 425849
Copyright notice ©2008, American College of Sports Medicine
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