Molecular mechanisms of inflammation : anti-inflammatory benefits of virgin olive oil and the phenolic compound oleocanthal

Lucas, Lisa, Russell, Aaron and Keast, Russell 2011, Molecular mechanisms of inflammation : anti-inflammatory benefits of virgin olive oil and the phenolic compound oleocanthal, Current pharmaceutical design, vol. 17, no. 8, pp. 754-768.

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Title Molecular mechanisms of inflammation : anti-inflammatory benefits of virgin olive oil and the phenolic compound oleocanthal
Author(s) Lucas, Lisa
Russell, AaronORCID iD for Russell, Aaron
Keast, RussellORCID iD for Keast, Russell
Journal name Current pharmaceutical design
Volume number 17
Issue number 8
Start page 754
End page 768
Total pages 15
Publisher Bentham Science Publishers
Place of publication Bussum, The Netherlands
Publication date 2011
ISSN 1381-6128
Keyword(s) Oleocanthal
Mediterranean diet
virgin olive oil phenolics
Summary Chronic inflammation is a critical factor in the pathogenesis of many inflammatory disease states including cardiovascular disease, cancer, diabetes, degenerative joint diseases and neurodegenerative diseases. Chronic inflammatory states are poorly understood, however it is known that dietary habits can evoke or attenuate inflammatory responses. Popular methods to deal with inflammation and its associated symptoms involve the use of non steroidal anti-inflammatory drugs, however the use of these drugs are associated with severe side effects. Therefore, investigations concerned with natural methods of inflammatory control are warranted. A traditional Mediterranean diet has been shown to confer some protection against the pathology of chronic diseases through the attenuation of proinflammatory mediators and this has been partially attributed to the high intake of virgin olive oil accompanying this dietary regime. Virgin olive oil contains numerous phenolic compounds that exert potent anti-inflammatory actions. Of interest to this paper is the recently discovered phenolic compound oleocanthal. Oleocanthal is contained in virgin olive oil and possesses similar anti-inflammatory properties to ibuprofen. This pharmacological similarity has provoked interest in oleocanthal and the few studies conducted thus far have verified its anti-inflammatory and potential therapeutic actions. A review of the health benefits of the Mediterranean diet and antiinflammatory properties of virgin olive oil is presented with the additional emphasis on the pharmacological and anti-inflammatory properties of the phenolic compound oleocanthal.
Language eng
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
Socio Economic Objective 920411 Nutrition
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Grant ID NHMRC 479536
HERDC collection year 2011
Copyright notice ©2011, Bentham Science Publishers Ltd.
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Created: Mon, 13 Jun 2011, 11:59:26 EST by Penny Andrews

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