Glutathione : a novel treatment target in psychiatry

Berk, Michael, Ng, Felicity, Dean, Olivia, Dodd, Seetal and Bush, Ashley I. 2008, Glutathione : a novel treatment target in psychiatry, Trends in pharmacological sciences, vol. 29, no. 7, pp. 346-351, doi: 10.1016/

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Title Glutathione : a novel treatment target in psychiatry
Author(s) Berk, MichaelORCID iD for Berk, Michael
Ng, Felicity
Dean, OliviaORCID iD for Dean, Olivia
Dodd, SeetalORCID iD for Dodd, Seetal
Bush, Ashley I.
Journal name Trends in pharmacological sciences
Volume number 29
Issue number 7
Start page 346
End page 351
Total pages 6
Publisher Elsevier
Place of publication London, England
Publication date 2008-07
ISSN 0165-6147
Summary There is accumulating evidence for oxidative stress mechanisms as common pathophysiological pathways in diverse psychiatric disorders, which offers novel treatment targets in oxidation biology systems. Of these the glutathione system has the most favourable theoretical foundation, given its dominance as the most generic of cellular antioxidants. Clinically, this hypothesis has been supported by several recently published studies that have reported on the efficacy of N-acetylcysteine, a glutathione precursor, in the treatment of various psychiatric disorders. This article outlines the multidimensional evidence that currently exists for oxidative stress mechanisms in psychiatric disorders and specifically discusses glutathione as a promising novel therapeutic target.
Language eng
DOI 10.1016/
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2008, Elsevier
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Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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