N-acetylcysteine in psychiatry - current therapeutic evidence and potential mechanisms of action Dean, Olivia, Giorlando, Frank and Berk, Michael 2011, N-acetylcysteine in psychiatry - current therapeutic evidence and potential mechanisms of action, Journal of psychiatry and neuroscience, vol. 36, no. 2, pp. 78-86. Attached Files Name Description MIMEType Size Downloads dean-nacetylcysteine-2010.pdf Published version application/pdf 203.68KB 1549 Title N-acetylcysteine in psychiatry - current therapeutic evidence and potential mechanisms of action Author(s) Dean, Olivia orcid.org/0000-0002-2776-3935 Giorlando, Frank Berk, Michael orcid.org/0000-0002-5554-6946 Journal name Journal of psychiatry and neuroscience Volume number 36 Issue number 2 Start page 78 End page 86 Total pages 9 Publisher Canadian Medical Association Place of publication Ottowa, Canada Publication date 2011 ISSN 1488-2434 1180-4882 Summary There is an expanding field of research investigating the benefits of alternatives to current pharmacological therapies in psychiatry. N-acetylcysteine (NAC) is emerging as a useful agent in the treatment of psychiatric disorders. Like many therapies, the clinical origins of NAC are far removed from its current use in psychiatry. Whereas the mechanisms of NAC are only beginning to be understood, it is likely that NAC is exerting benefits beyond being a precursor to the antioxidant, glutathione, modulating glutamatergic, neurotropic and inflammatory pathways. This review outlines the current literature regarding the use of NAC in disorders including addiction, compulsive and grooming disorders, schizophrenia and bipolar disorder. N-acetylcysteine has shown promising results in populations with these disorders, including those in whom treatment efficacy has previously been limited. The therapeutic potential of this acetylated amino acid is beginning to emerge in the field of psychiatric research. Notes First published online: June 24, 2010 Language eng Field of Research 119999 Medical and Health Sciences not elsewhere classified Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1.1 Refereed article in a scholarly journal Copyright notice ©2011, Canadian Medical Association Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30035469 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Tue, 21 Jun 2011, 14:39:14 EST Thu, 06 Oct 2011, 10:09:58 EST Thu, 06 Oct 2011, 10:11:27 EST Tue, 11 Oct 2011, 10:58:18 EST Thu, 02 Feb 2012, 07:58:00 EST Mon, 20 Feb 2012, 09:26:18 EST Tue, 06 Mar 2012, 10:33:23 EST Tue, 24 Sep 2013, 09:39:41 EST Tue, 06 Sep 2016, 17:13:49 EST Tue, 05 Dec 2017, 10:51:19 EST Fri, 07 Sep 2018, 15:27:54 EST Filtered Full Citation counts:   Cited 309 times in TR Web of Science Cited 330 times in Scopus Search Google Scholar Access Statistics: 968 Abstract Views, 1549 File Downloads  -  Detailed Statistics Created: Tue, 21 Jun 2011, 14:39:14 EST