Oxidative pathways as a drug target for the treatment of autism

Villagonzalo, Kristi-Ann, Dodd, Seetal, Dean, Olivia, Gray, Kylie, Tonge, Bruce and Berk, Michael 2010, Oxidative pathways as a drug target for the treatment of autism, Expert opinion on therapeutic targets, vol. 14, no. 12, pp. 1301-1310, doi: 10.1517/14728222.2010.528394.

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Title Oxidative pathways as a drug target for the treatment of autism
Author(s) Villagonzalo, Kristi-Ann
Dodd, SeetalORCID iD for Dodd, Seetal orcid.org/0000-0002-7918-4636
Dean, OliviaORCID iD for Dean, Olivia orcid.org/0000-0002-2776-3935
Gray, Kylie
Tonge, Bruce
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Journal name Expert opinion on therapeutic targets
Volume number 14
Issue number 12
Start page 1301
End page 1310
Total pages 10
Publisher Informa Healthcare
Place of publication London, England
Publication date 2010-12
ISSN 1472-8222
Keyword(s) antioxidant treatment
autistic disorder
oxidative stress
Summary Importance of the field: Autism is a severe, pervasive developmental disorder, the aetiology of which is poorly understood. Current pharmacological treatment options for autism are often focused on addressing comorbid behavioural problems, rather than core features of the disorder. Investigation of a new treatment approach is needed.

Areas covered in this review: Recent research has indicated a possible role of abnormalities in oxidative homeostasis in the pathophysiology of autism, based on reports that a range of oxidative biomarkers are significantly altered in people with autism. This article reviews the current findings on oxidative stress in autism, including genetic links to oxidative pathways, changes in antioxidant levels and other oxidative stress markers. We conducted a search of the literature up to June 2010, using Medline, Pubmed, PsycINFO, CINAHL PLUS and BIOSIS Previews.

What the reader will gain: This review provides an overview of the current understanding of the role of oxidative stress in autism. This will assist in highlighting areas of future therapeutic targets and potential underlying pathophysiology of this disorder.

Take home message: Abnormalities in oxidative homeostasis may play a role in the pathophysiology of autism. Antioxidant treatment may form a potential therapeutic pathway for this complex disorder.
Language eng
DOI 10.1517/14728222.2010.528394
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2011, Informa Healthcare
Persistent URL http://hdl.handle.net/10536/DRO/DU:30035481

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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