Restless leg syndrome caused by olanzapine: a case series Aggarwal, Shilpa, Dodd, Seetal and Berk, Michael 2010, Restless leg syndrome caused by olanzapine: a case series, Current drug safety, vol. 5, no. 2, pp. 129-131, doi: 10.2174/157488610790936187. Attached Files Name Description MIMEType Size Downloads Title Restless leg syndrome caused by olanzapine: a case series Author(s) Aggarwal, Shilpa Dodd, Seetal orcid.org/0000-0002-7918-4636 Berk, Michael orcid.org/0000-0002-5554-6946 Journal name Current drug safety Volume number 5 Issue number 2 Start page 129 End page 131 Total pages 3 Publisher Bentham Science Publishers Place of publication San Francisco, Ca. Publication date 2010-04 ISSN 1574-8863 2212-3911 Keyword(s) Restless legs syndrome olanzapine Summary Restless leg syndrome (RLS) is a common disorder associated with significant distress. We report three cases of drug induced RLS caused by olanzapine. In each case, RLS commenced after initiation of treatment with olanzapine and resolved after ceasing olanzapine. All three patients were subsequently treated with other atypical antipsychotics, risperidone, quetiapine or aripiprazole, without re-emergence of RLS. RLS is associated with central dopaminergic dysfunction. Dopamine agonists and l-dopa reduce the symptoms of RLS, and some agents that block the dopaminergic system aggravate RLS. Greater awareness of potential causes of RLS, and its differentiation from akathisia and illness related agitation might help in reducing the distress associated with it and improving patient compliance. Language eng DOI 10.2174/157488610790936187 Field of Research 119999 Medical and Health Sciences not elsewhere classified Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1.1 Refereed article in a scholarly journal Copyright notice ©2010, Bentham Science Publishers Persistent URL http://hdl.handle.net/10536/DRO/DU:30035517 Document type: Journal Article Collections: Faculty of Health School of Medicine Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Wed, 22 Jun 2011, 12:32:27 EST Tue, 04 Oct 2011, 11:06:32 EST Tue, 04 Oct 2011, 11:07:53 EST Tue, 04 Oct 2011, 11:08:59 EST Tue, 11 Oct 2011, 11:17:28 EST Fri, 19 Jul 2013, 09:53:49 EST Mon, 16 Jun 2014, 18:21:09 EST Thu, 11 Dec 2014, 17:10:08 EST Filtered Full Citation counts:   Cited 22 times in TR Web of Science Cited 26 times in Scopus Search Google Scholar Access Statistics: 815 Abstract Views, 2 File Downloads  -  Detailed Statistics Created: Wed, 22 Jun 2011, 12:32:27 EST