The impact of age at onset of bipolar I disorder on functioning and clinical presentation

Biffin, Frances, Tahtalian, Steven, Filia, Kate, Fitzgerald, Paul B., De Castella, Anthony R., Filia, Sacha, Berk, Michael, Dodd, Seetal, Callaly, Pam, Berk, Lesley, Kelin, Katarina, Smith, Meg, Montgomery, William and Kulkarni, Jayashri 2009, The impact of age at onset of bipolar I disorder on functioning and clinical presentation, Acta neuropsychiatrica, vol. 21, no. 4, pp. 191-196, doi: 10.1111/j.1601-5215.2009.00399.x.

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Title The impact of age at onset of bipolar I disorder on functioning and clinical presentation
Author(s) Biffin, Frances
Tahtalian, Steven
Filia, Kate
Fitzgerald, Paul B.
De Castella, Anthony R.
Filia, Sacha
Berk, MichaelORCID iD for Berk, Michael
Dodd, SeetalORCID iD for Dodd, Seetal
Callaly, Pam
Berk, LesleyORCID iD for Berk, Lesley
Kelin, Katarina
Smith, Meg
Montgomery, William
Kulkarni, Jayashri
Journal name Acta neuropsychiatrica
Volume number 21
Issue number 4
Start page 191
End page 196
Total pages 6
Publisher Wiley Blackwell
Place of publication Oxford, England
Publication date 2009-08
ISSN 0924-2708
Keyword(s) bipolar disorder
Summary Objectives: Recent studies have proposed the existence of three distinct subgroups of bipolar 1 disorder based on age at onset (AAO). The present study aims to investigate potential clinical and functional differences between these subgroups in an Australian sample.

Methods: Participants (n = 239) were enrolled in the Bipolar Comprehensive Outcomes Study (BCOS), a 2-year longitudinal, observational, cross-sectional study. Assessment measures included the Young Mania Rating Scale (YMRS), Hamilton Depression Rating Scale (HAMD21), Clinical Global Impressions Scale (CGI-BP), SF-36, SLICE/Life Scale, and the EuroQol (EQ-5D). Participants were also asked about their age at the first major affective episode.

Results: Three AAO groups were compared: early (AAO < 20, mean = 15.5 ± 2.72; 44.4% of the participants); intermediate (AAO 20–39, mean = 26.1 ± 4.8; 48.14% of the participants) and late (AAO > 40, mean = 50.6 ± 9.04; 7.4% of the participants). Higher rates of depression, suicidal ideation and binge drinking were reported by the early AAO group. This group also reported poorer quality of life in a number of areas. The early AAO group had a predominant depressive initial polarity and the intermediate group had a manic predominance.

Conclusion: Early AAO is associated with an adverse outcome.
Language eng
DOI 10.1111/j.1601-5215.2009.00399.x
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2009, John Wiley & Sons
Persistent URL

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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