A review of clozapine safety

Fitzsimons, Joanna, Berk, Michael, Lambert, Timothy, Bourin, Michel and Dodd, Seetal 2005, A review of clozapine safety, Expert opinion on drug safety, vol. 4, no. 4, pp. 731-744, doi: 10.1517/14740338.4.4.731.

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Title A review of clozapine safety
Author(s) Fitzsimons, Joanna
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Lambert, Timothy
Bourin, Michel
Dodd, SeetalORCID iD for Dodd, Seetal orcid.org/0000-0002-7918-4636
Journal name Expert opinion on drug safety
Volume number 4
Issue number 4
Start page 731
End page 744
Publisher Informa Healthcare
Place of publication London, England
Publication date 2005-07
ISSN 1474-0338
Keyword(s) adverse effect
drug therapy
drug-induced induced myocarditis/cardiomyopathy
drug-induced agranulocytosis
antipsychotic agent
Summary Clozapine is a distinctive antipsychotic agent, having a unique clinical profile and an idiosyncratic safety profile. More so than with other agents, the weighting of its adverse event profile is critical, in order to counterbalance its clear clinical advantages. The safety issues with clozapine are in a number of areas, some of which are considered medical emergencies and potentially life-threatening. These include haematological (neutropenia and agranulocytosis), CNS (seizures), cardiovascular (myocarditis and cardiomyopathy), metabolic (diabetes), gastrointestinal and neuromuscular. Understanding the safety profile of clozapine allows an informed use of the agent that can maximise its clear clinical benefit and minimise the known risks.
Language eng
DOI 10.1517/14740338.4.4.731
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2005, Informa Healthcare
Persistent URL http://hdl.handle.net/10536/DRO/DU:30035620

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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