A review of clozapine safety Fitzsimons, Joanna, Berk, Michael, Lambert, Timothy, Bourin, Michel and Dodd, Seetal 2005, A review of clozapine safety, Expert opinion on drug safety, vol. 4, no. 4, pp. 731-744, doi: 10.1517/14740338.4.4.731. Attached Files Name Description MIMEType Size Downloads Title A review of clozapine safety Author(s) Fitzsimons, Joanna Berk, Michael orcid.org/0000-0002-5554-6946 Lambert, Timothy Bourin, Michel Dodd, Seetal orcid.org/0000-0002-7918-4636 Journal name Expert opinion on drug safety Volume number 4 Issue number 4 Start page 731 End page 744 Publisher Informa Healthcare Place of publication London, England Publication date 2005-07 ISSN 1474-0338 1744-764X Keyword(s) adverse effect schizophrenia pharmacology drug therapy drug-induced induced myocarditis/cardiomyopathy drug-induced agranulocytosis clozapine antipsychotic agent Summary Clozapine is a distinctive antipsychotic agent, having a unique clinical profile and an idiosyncratic safety profile. More so than with other agents, the weighting of its adverse event profile is critical, in order to counterbalance its clear clinical advantages. The safety issues with clozapine are in a number of areas, some of which are considered medical emergencies and potentially life-threatening. These include haematological (neutropenia and agranulocytosis), CNS (seizures), cardiovascular (myocarditis and cardiomyopathy), metabolic (diabetes), gastrointestinal and neuromuscular. Understanding the safety profile of clozapine allows an informed use of the agent that can maximise its clear clinical benefit and minimise the known risks. Language eng DOI 10.1517/14740338.4.4.731 Field of Research 119999 Medical and Health Sciences not elsewhere classified Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1.1 Refereed article in a scholarly journal Copyright notice ©2005, Informa Healthcare Persistent URL http://hdl.handle.net/10536/DRO/DU:30035620 Document type: Journal Article Collections: Faculty of Health School of Medicine Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Wed, 22 Jun 2011, 12:40:19 EST Tue, 18 Oct 2011, 13:53:11 EST Tue, 18 Oct 2011, 13:54:49 EST Fri, 19 Jul 2013, 09:53:12 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 63 times in Scopus Search Google Scholar Access Statistics: 672 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Wed, 22 Jun 2011, 12:40:19 EST

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