Atypical antipsychotics for bipolar disorder : overblown or blown over? Ng, Felicity, Dodd, Seetal and Berk, Michael 2007, Atypical antipsychotics for bipolar disorder : overblown or blown over?, Clinical psychopharmacology and neuroscience, vol. 5, no. 2, pp. 53-64. Attached Files Name Description MIMEType Size Downloads dodd-atypical-2007.pdf Published version application/pdf 317.41KB 216 Title Atypical antipsychotics for bipolar disorder : overblown or blown over? Author(s) Ng, Felicity Dodd, Seetal orcid.org/0000-0002-7918-4636 Berk, Michael orcid.org/0000-0002-5554-6946 Journal name Clinical psychopharmacology and neuroscience Volume number 5 Issue number 2 Start page 53 End page 64 Publisher Korean College of Neuropsychopharmacology Place of publication Seoul, Korea Publication date 2007-07 ISSN 1738-1088 2093-4327 Keyword(s) bipolar disorder clinical trials maintenance depression mania atypical antipsychotics Summary Objective：Developments in the pharmacological treatment of bipolar disorder are of much interest, as the chronicity and disability of the disorder become better understood, and as treatment goals have shifted to emphasise early control of illness course and maintenance of euthymia in addition to acute episodic remission. Atypical antipsychotics have emerged as treatment options, and this paper aims to review the evidence for their role in bipolar disorder. Methods：A MEDLINE search was conducted for publications up till October 2006. Results：The search yielded a number of randomised, controlled clinical trials of various atypical antipsychotics as monotherapy or adjunctive therapy in bipolar disorder. The majority of such trials have investigated their efficacy in acute mania, with fewer studies devoted to acute bipolar depression or maintenance treatment. There are no specific trials on mixed states, which have mainly been studied together with bipolar mania. The most robust evidence supports a class effect of atypical agents in the treatment of mania. Conclusions：There are placebo-controlled trials that support the efficacy of olanzapine and quetiapine in bipolar depression, and of olanzapine and aripiprazole as maintenance treatment. There is strong support for the role of atypical antipsychotics in bipolar disorder management despite a relatively narrow literature base, chiefly for the treatment of mania. However, these findings need to be replicated, and further investigation is warranted to clarify their spectrum of efficacy in bipolar disorder. Language eng Field of Research 119999 Medical and Health Sciences not elsewhere classified Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1.1 Refereed article in a scholarly journal Copyright notice ©2007, Korean College of Neuropsychopharmacology Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30035667 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Wed, 22 Jun 2011, 12:43:21 EST Mon, 17 Oct 2011, 13:03:44 EST Mon, 17 Oct 2011, 13:12:26 EST Mon, 17 Oct 2011, 13:13:08 EST Mon, 17 Oct 2011, 13:15:14 EST Wed, 08 Feb 2012, 15:17:26 EST Fri, 10 Feb 2012, 08:54:06 EST Wed, 21 Oct 2015, 14:03:18 EST Tue, 05 Dec 2017, 10:51:37 EST Fri, 07 Sep 2018, 15:28:25 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 2 times in Scopus Search Google Scholar Access Statistics: 788 Abstract Views, 235 File Downloads  -  Detailed Statistics Created: Wed, 22 Jun 2011, 12:43:21 EST