Three-month bilateral hopping intervention is ineffective in initiating bone biomarker response in healthy elderly men. Rantalainen, Timo, Hoffrén, M., Linnamo, V., Heinonen, A., Komi, P. V., Avela, J. and Nindl, B. C. 2011, Three-month bilateral hopping intervention is ineffective in initiating bone biomarker response in healthy elderly men., European journal of applied physiology, vol. 111, no. 9, pp. 2155-2162, doi: 10.1007/s00421-011-1849-8. Attached Files Name Description MIMEType Size Downloads Title Three-month bilateral hopping intervention is ineffective in initiating bone biomarker response in healthy elderly men. Author(s) Rantalainen, Timo orcid.org/0000-0001-6977-4782 Hoffrén, M. Linnamo, V. Heinonen, A. Komi, P. V. Avela, J. Nindl, B. C. Journal name European journal of applied physiology Volume number 111 Issue number 9 Start page 2155 End page 2162 Total pages 7 Publisher Springer Berlin / Heidelberg Place of publication Berlin, Germany Publication date 2011-02-06 ISSN 1439-6319 1439-6327 Keyword(s) randomized controlled study RCT bone biochemical markers exercise impact Summary In animal studies, bone adaptation has been initiated successfully without the transient force spike associated with high impact exercises. Consequently, a 12-week bilateral hopping on the balls of the feet intervention was conducted. 25 elderly men (age 72(SD4) years, height 171(6) cm, weight 75(9) kg) were randomly assigned into exercise and control groups. Ten subjects in each group completed the study. Carboxyterminal propeptide of type I collagen (CICP), bone-specific alkaline phosphatase (bALP) and carboxyterminal telopeptide of type I collagen (CTx) were measured from venous blood samples at baseline, at 2 weeks and at the end of the intervention. Maximal ground reaction force (GRF), osteogenic index (OI) and jump height (JH) were determined from bilateral hopping test and balance was assessed with velocity of center of pressure (COPvelocity) while standing on the preferred leg with eyes open. The intervention consisted of 5–7 sets of 10 s timed bilateral hopping exercise at 75–90% intensity three times/week. There was no significant group 9 time interaction for GRF, OI and JH (P = 0.065). GRF (11% change from baseline vs. 4%), OI (15 vs. 6%) and COPvelocity (-10 vs. -1%) were not influenced by the intervention (P[0.170), while the control group improved JH (P = 0.031) (2 vs. 18%). For the biomarkers, no effect was observed in MANOVA (P = 0.536) or in univariate analyses (P = 0.082 to P = 0.820) (CICP -2 vs. -3%, CTx 8 vs. -12%, bALP 0 vs. -3.7%). Allowing transient impact force spikes may be necessary to initiate a bone response in elderly men as the intervention was ineffective. Language eng DOI 10.1007/s00421-011-1849-8 Field of Research 119999 Medical and Health Sciences not elsewhere classified Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1.1 Refereed article in a scholarly journal Copyright notice ©2011, Springer-Verlag Persistent URL http://hdl.handle.net/10536/DRO/DU:30036195 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Tue, 09 Aug 2011, 16:19:35 EST Thu, 29 Sep 2011, 10:36:22 EST Thu, 29 Sep 2011, 11:10:00 EST Thu, 29 Sep 2011, 11:11:06 EST Thu, 29 Sep 2011, 11:12:13 EST Thu, 29 Sep 2011, 11:47:07 EST Thu, 02 Feb 2012, 14:23:57 EST Mon, 17 Jun 2013, 16:52:44 EST Tue, 18 Jun 2013, 13:56:11 EST Mon, 16 Jun 2014, 18:38:00 EST Thu, 11 Dec 2014, 17:15:30 EST Filtered Full Citation counts:   Cited 12 times in TR Web of Science Cited 13 times in Scopus Search Google Scholar Access Statistics: 465 Abstract Views, 3 File Downloads  -  Detailed Statistics Created: Tue, 09 Aug 2011, 16:19:35 EST