'Forbidden' disulfides : their role as redox switches

Wouters, M. A., George, R. A. and Haworth, N. L. 2007, 'Forbidden' disulfides : their role as redox switches, Current protein and peptide science, vol. 8, no. 5, pp. 484-495.

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Title 'Forbidden' disulfides : their role as redox switches
Author(s) Wouters, M. A.
George, R. A.
Haworth, N. L.
Journal name Current protein and peptide science
Volume number 8
Issue number 5
Start page 484
End page 495
Total pages 13
Publisher Bentham Science Publishers
Place of publication Bussum, The Netherlands
Publication date 2007-10
ISSN 1389-2037
Summary Seminal studies by Richardson and Thornton defined the constraints imposed by protein structure on disulfide formation and flagged forbidden regions of primary or secondary structure seemingly incapable of forming disulfide bonds between resident cysteine pairs. With respect to secondary structure, disulfide bonds were not found between cysteine pairs: A. on adjacent beta-stands; B. in a single helix or strand; C. on non-adjacent strands of the same beta-sheet. In primary structure, disulfide bonds were not found between cysteine pairs: D. adjacent in the sequence. In the intervening years it has become apparent that all these forbidden regions are indeed occupied by disulfide-bonded cysteines, albeit rather strained ones. It has been observed that sources of strain in a protein structure, such as residues in forbidden regions of the Ramachandran plot and cis-peptide bonds, are found in functionally important regions of the protein and warrant further investigation. Like the Ramachandran plot, the earlier studies by Richardson and Thornton have identified a fundamental truth in protein stereochemistry: "forbidden" disulfides adopt strained conformations, but there is likely a functional reason for this. Emerging evidence supports a role for forbidden disulfides in redox-regulation of proteins.
Language eng
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970105 Expanding Knowledge in the Environmental Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2007, Bentham Science Publishers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30038991

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