A role for SSU72 in balancing RNA polymerase II transcription elongation and termination Dichtl, Bernhard, Blank, Diana, Ohnacker, Martin, Friedlein, Arno, Roeder, Daniel, Langen, Hanno and Keller, Walter 2002, A role for SSU72 in balancing RNA polymerase II transcription elongation and termination, Molecular cell, vol. 10, no. 5, pp. 1139-1150, doi: 10.1016/S1097-2765(02)00707-4. Attached Files Name Description MIMEType Size Downloads dichtl-roleforssu72-2002.pdf Published version application/pdf 644.94KB 270 Title A role for SSU72 in balancing RNA polymerase II transcription elongation and termination Author(s) Dichtl, Bernhard orcid.org/0000-0001-5514-4982 Blank, Diana Ohnacker, Martin Friedlein, Arno Roeder, Daniel Langen, Hanno Keller, Walter Journal name Molecular cell Volume number 10 Issue number 5 Start page 1139 End page 1150 Total pages 12 Publisher Cell Press Place of publication Cambridge, Mass. Publication date 2002-11-01 ISSN 1097-2765 1097-4164 Keyword(s) azauracil RNA polymerase II transcription factor Summary Interactions of pre-mRNA 3′end factors and the CTD of RNA polymerase II (RNAP II) are required for transcription termination and 3′end processing. Here, we demonstrate that Ssu72p is stably associated with yeast cleavage and polyadenylation factor CPF and provide evidence that it bridges the CPF subunits Pta1p and Ydh1p/Cft2p, the general transcription factor TFIIB, and RNAP II via Rpb2p. Analyses of ssu72-2 mutant cells in the absence and presence of the nuclear exosome component Rrp6p revealed defects in RNAP II transcription elongation and termination. 6-azauracil, that reduces transcription elongation rates, suppressed the ssu72-2 growth defect at 33°C. The sum of our analyses suggests a negative influence of Ssu72p on RNAP II during transcription that affects the commitment to either elongation or termination. Language eng DOI 10.1016/S1097-2765(02)00707-4 Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences HERDC Research category C1.1 Refereed article in a scholarly journal Copyright notice ©2002, Elsevier Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30039332 Document type: Journal Article Collections: Faculty of Science, Engineering and Built Environment School of Life and Environmental Sciences Open Access Collection Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Mon, 24 Oct 2011, 14:18:52 EST Tue, 29 Jan 2013, 08:32:36 EST Tue, 29 Jan 2013, 08:35:18 EST Mon, 13 May 2013, 11:07:01 EST Tue, 06 Sep 2016, 17:35:29 EST Tue, 05 Dec 2017, 10:53:38 EST Fri, 07 Sep 2018, 15:33:12 EST Filtered Full Citation counts:   Cited 134 times in TR Web of Science Cited 135 times in Scopus Search Google Scholar Access Statistics: 587 Abstract Views, 270 File Downloads  -  Detailed Statistics Created: Mon, 24 Oct 2011, 14:18:52 EST