Membrane bound members of the M1 family : more than aminopeptidases

Albiston, Anthony L., Ye, Siying and Chai, Siew Yeen 2004, Membrane bound members of the M1 family : more than aminopeptidases, Protein and peptide letters, vol. 11, no. 5, pp. 491-500, doi: 10.2174/0929866043406643.

Attached Files
Name Description MIMEType Size Downloads

Title Membrane bound members of the M1 family : more than aminopeptidases
Author(s) Albiston, Anthony L.
Ye, SiyingORCID iD for Ye, Siying
Chai, Siew Yeen
Journal name Protein and peptide letters
Volume number 11
Issue number 5
Start page 491
End page 500
Total pages 10
Publisher Bentham Science Publishers
Place of publication Bussum, The Netherlands
Publication date 2004-10
ISSN 0929-8665
Keyword(s) aminopeptidase
Angiotensin IV
Summary In mammals the M1 aminopeptidase family consists of nine different proteins, five of which are integral membrane proteins. The aminopeptidases are defined by two motifs in the catalytic domain; a zinc binding motif HEXXH-(X18)-E and an exopeptidase motif GXMEN. Aminopeptidases of this family are able to cleave a broad range of peptides down to only to a single peptide. This ability to either generate or degrade active peptide hormones is the focus of this review. In addition to their capacity to degrade a range of peptides a number of these aminopeptidases have novel functions that impact on cell signalling and will be discussed.
Language eng
DOI 10.2174/0929866043406643
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Persistent URL

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Connect to link resolver
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 58 times in TR Web of Science
Scopus Citation Count Cited 61 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 345 Abstract Views, 1 File Downloads  -  Detailed Statistics
Created: Wed, 07 Dec 2011, 10:04:55 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact