Associations of the SREBP-1c gene polymorphism with gender-specific changes in serum lipids induced by a high-carbohydrate diet in healthy Chinese youth Zhang, Zhen, Gong, Ren Rong, Du, Juan, Xiao, Li Ying, Duan, Wei, Zhou, Xue Dong and Fang, Ding Zhi 2011, Associations of the SREBP-1c gene polymorphism with gender-specific changes in serum lipids induced by a high-carbohydrate diet in healthy Chinese youth, Applied physiology, nutrition and metabolism, vol. 36, no. 2, pp. 226-232, doi: 10.1139/h11-005. Attached Files Name Description MIMEType Size Downloads Title Associations of the SREBP-1c gene polymorphism with gender-specific changes in serum lipids induced by a high-carbohydrate diet in healthy Chinese youth Author(s) Zhang, Zhen Gong, Ren Rong Du, Juan Xiao, Li Ying Duan, Wei orcid.org/0000-0001-5782-9184 Zhou, Xue Dong Fang, Ding Zhi Journal name Applied physiology, nutrition and metabolism Volume number 36 Issue number 2 Start page 226 End page 232 Total pages 7 Publisher NRC Research Press Place of publication Ottawa, Canada Publication date 2011-04 ISSN 1715-5312 1715-5320 Keyword(s) sterol regulatory element-binding protein-1c personalized nutrition hypertriacylglycerolemia coronary heart disease Summary We investigated the possible association between the sterol regulatory element-binding protein-1c gene (SREBP-1c) rs2297508 polymorphism and the changes in lipid profiles in a high-carbohydrate and low-fat (high-CHO/LF) diet in a Chinese population well characterized by a lower incidence of coronary heart disease and a diet featuring higher carbohydrate and lower fat. Fifty-six healthy youth (aged 22.89 ± 1.80 years) were given wash-out diets of 31% fat and 54% carbohydrate for 7 days, followed by the high-CHO/LF diet of 15% fat and 70% carbohydrate for 6 days, without total energy restriction. Fasting blood samples were collected. Serum variables of lipid and glucose metabolism after the wash-out and high-CHO/LF diets, as well as the rs2297508 polymorphism, were analyzed. Compared with the male subjects on the wash-out diet, significantly elevated levels of high-density lipoprotein cholesterol (HDL-C) and decreased levels of apolipoprotein B-100 were observed in the male carriers of the C allele after the high-CHO/LF diet. In the female subjects, significantly increased triacylglycerol levels, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) were found in the GG genotype after the high-CHO/LF diet. These results suggest that the C allele of the rs2297508 polymorphism is associated with a retardation of the increases in serum triacylglycerol, serum insulin, and HOMA-IR in females and with the elevated serum HDL-C in males after the high-CHO/LF diet. Language eng DOI 10.1139/h11-005 Field of Research 111102 Dietetics and Nutrigenomics Socio Economic Objective 920411 Nutrition HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2011, NRC Research Press Persistent URL http://hdl.handle.net/10536/DRO/DU:30042588 Document type: Journal Article Collections: Faculty of Health School of Medicine Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Wed, 22 Feb 2012, 11:03:59 EST Wed, 22 Feb 2012, 13:55:20 EST Wed, 22 Feb 2012, 13:56:48 EST Fri, 13 Jun 2014, 12:59:22 EST Tue, 08 Jul 2014, 08:23:27 EST Tue, 08 Jul 2014, 08:24:49 EST Fri, 03 Oct 2014, 14:28:53 EST Filtered Full Citation counts:   Cited 11 times in TR Web of Science Cited 11 times in Scopus Search Google Scholar Access Statistics: 718 Abstract Views, 3 File Downloads  -  Detailed Statistics Created: Wed, 22 Feb 2012, 11:03:51 EST by Jane Moschetti