Origins of adaptive immunity Liongue, Clifford, John, Liza and Ward, Alister 2011, Origins of adaptive immunity, Critical reviews in immunology, vol. 31, no. 1, pp. 61-71. Attached Files Name Description MIMEType Size Downloads Title Origins of adaptive immunity Author(s) Liongue, Clifford orcid.org/0000-0002-1646-4905 John, Liza Ward, Alister orcid.org/0000-0001-7945-7975 Journal name Critical reviews in immunology Volume number 31 Issue number 1 Start page 61 End page 71 Total pages 11 Publisher Begell House Inc. Place of publication Redding, Conn. Publication date 2011 ISSN 1040-8401 2162-6472 Keyword(s) adaptive immunity evolution BCR TCR MHC RAG cytokine signaling transcription factors Summary Adaptive immunity, involving distinctive antibody- and cell-mediated responses to specific antigens based on "memory" of previous exposure, is a hallmark of higher vertebrates. It has been argued that adaptive immunity arose rapidly, as articulated in the "big bang theory" surrounding its origins, which stresses the importance of coincident whole-genome duplications. Through a close examination of the key molecules and molecular processes underpinning adaptive immunity, this review suggests a less-extreme model, in which adaptive immunity emerged as part of longer evolutionary journey. Clearly, whole-genome duplications provided additional raw genetic materials that were vital to the emergence of adaptive immunity, but a variety of other genetic events were also required to generate some of the key molecules, whereas others were preexisting and simply co-opted into adaptive immunity. Language eng Field of Research 110704 Cellular Immunology Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article HERDC collection year 2011 Persistent URL http://hdl.handle.net/10536/DRO/DU:30042859 Document type: Journal Article Collections: Faculty of Health School of Medicine   Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Fri, 02 Mar 2012, 13:30:41 EST Mon, 05 Mar 2012, 12:58:48 EST Mon, 05 Mar 2012, 12:59:28 EST Mon, 17 Jun 2013, 17:30:05 EST Mon, 30 Jun 2014, 08:39:32 EST Tue, 22 Jul 2014, 09:07:08 EST Tue, 22 Jul 2014, 09:07:48 EST Wed, 23 Jul 2014, 11:39:11 EST Wed, 23 Jul 2014, 11:40:28 EST Fri, 22 Aug 2014, 15:17:24 EST Fri, 17 Oct 2014, 11:22:40 EST Filtered Full Citation counts:   Cited 6 times in TR Web of Science Cited 9 times in Scopus Search Google Scholar Access Statistics: 882 Abstract Views, 2 File Downloads  -  Detailed Statistics Created: Fri, 02 Mar 2012, 13:30:30 EST by Penny Andrews