Short-term exercise training early in life restores deficits in pancreatic B-cell mass associated with growth restriction in adult male rats Laker, Rhianna C., Gallo, Linda A., Wlodek, Mary E., Siebel, Andrew L., Wadley, Glenn D. and McConell, Glenn K. 2011, Short-term exercise training early in life restores deficits in pancreatic B-cell mass associated with growth restriction in adult male rats, AJP : endocrinology and metabolism, vol. 301, no. 5, pp. 931-940, doi: 10.1152/ajpendo.00114.2011. Attached Files Name Description MIMEType Size Downloads Title Short-term exercise training early in life restores deficits in pancreatic B-cell mass associated with growth restriction in adult male rats Formatted title Short-term exercise training early in life restores deficits in pancreatic ß-cell mass associated with growth restriction in adult male rats Author(s) Laker, Rhianna C. Gallo, Linda A. Wlodek, Mary E. Siebel, Andrew L. Wadley, Glenn D. orcid.org/0000-0002-6617-4359 McConell, Glenn K. Journal name AJP : endocrinology and metabolism Volume number 301 Issue number 5 Start page 931 End page 940 Total pages 10 Publisher American Physiological Society Place of publication Bethesda, Md. Publication date 2011-11 ISSN 0193-1849 1522-1555 Keyword(s) b-cell fetal size insulin secretion Summary Fetal growth restriction is associated with reduced pancreatic ß-cell mass, contributing to impaired glucose tolerance and diabetes. Exercise training increases ß-cell mass in animals with diabetes and has long-lasting metabolic benefits in rodents and humans. We studied the effect of exercise training on islet and ß-cell morphology and plasma insulin and glucose, following an intraperitoneal glucose tolerance test (IPGTT) in juvenile and adult male Wistar-Kyoto rats born small. Bilateral uterine vessel ligation performed on day 18 of pregnancy resulted in Restricted offspring born small compared with shamoperated Controls and also sham-operated Reduced litter offspring that had their litter size reduced to five pups at birth. Restricted, Control, and Reduced litter offspring remained sedentary or underwent treadmill running from 5 to 9 or 20 to 24 wk of age. Early life exercise increased relative islet surface area and ß-cell mass across all groups at 9 wk, partially restoring the 60–68% deficit (P = 0.05) in Restricted offspring. Remarkably, despite no further exercise training after 9 wk, ß-cell mass was restored in Restricted at 24 wk, while sedentary littermates retained a 45% deficit (P = 0.05) in relative ß-cell mass. Later exercise training also restored Restricted ß-cell mass to Control levels. In conclusion, early life exercise training in rats born small restored ß-cell mass in adulthood and may have beneficial consequences for later metabolic health and disease. Language eng DOI 10.1152/ajpendo.00114.2011 Field of Research 111603 Systems Physiology Socio Economic Objective 920104 Diabetes HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2011, American Physiological Society Persistent URL http://hdl.handle.net/10536/DRO/DU:30043840 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Institute for Physical Activity and Nutrition Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Thu, 22 Mar 2012, 12:02:58 EST Thu, 22 Mar 2012, 12:51:56 EST Thu, 22 Mar 2012, 12:53:36 EST Tue, 12 Nov 2013, 11:32:33 EST Fri, 13 Jun 2014, 13:16:48 EST Wed, 20 Aug 2014, 10:11:38 EST Wed, 27 Aug 2014, 22:56:38 EST Filtered Full Citation counts:   Cited 47 times in TR Web of Science Cited 47 times in Scopus Search Google Scholar Access Statistics: 610 Abstract Views, 3 File Downloads  -  Detailed Statistics Created: Thu, 22 Mar 2012, 12:02:44 EST by Jane Moschetti