Ribosome inactivating proteins from plants inhibiting viruses

Kaur, Inderdeep, Gupta, R. C. and Puri, Munish 2011, Ribosome inactivating proteins from plants inhibiting viruses, Virologica sinica, vol. 26, no. 6, pp. 357-365.

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Title Ribosome inactivating proteins from plants inhibiting viruses
Author(s) Kaur, Inderdeep
Gupta, R. C.
Puri, MunishORCID iD for Puri, Munish orcid.org/0000-0003-2469-3326
Journal name Virologica sinica
Volume number 26
Issue number 6
Start page 357
End page 365
Total pages 9
Publisher Springer
Place of publication Heidelberg, Germany
Publication date 2011-12
ISSN 1674-0769
Keyword(s) hepatitis B virus
herpes simplex virus
human immunodeficiency virus
ribosome inactivating protein
Summary Many plants contain ribosome inactivating proteins (RIPs) with N-glycosidase activity, which depurinate large ribosomal RNA and arrest protein synthesis. RIPs so far tested inhibit replication of mRNA as well as DNA viruses and these proteins, isolated from plants, are found to be effective against a broad range of viruses such as human immunodeficiency virus (HIV), hepatitis B virus (HBV) and herpes simplex virus (HSV). Most of the research work related to RIPs has been focused on antiviral activity against HIV; however, the exact mechanism of antiviral activity is still not clear. The mechanism of antiviral activity was thought to follow inactivation of the host cell ribosome, leading to inhibition of viral protein translation and host cell death. Enzymatic activity of RIPs is not limited to depurination of the large rRNA, in addition they can depurinate viral DNA as well as RNA. Recently, Phase I/II clinical trials have demonstrated the potential use of RIPs for treating patients with HIV disease. The aim of this review is to focus on various RIPs from plants associated with anti-HIV activity.
Language eng
Field of Research 100302 Bioprocessing, Bioproduction and Bioproducts
030406 Proteins and Peptides
060506 Virology
Socio Economic Objective 860303 Plant Extracts (e.g. Pyrethrum, Alkaloids, Jojoba Oil)
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2011, Wuhan Institute of Virology, CAS and Springer-Verlag Berlin Heidelberg
Persistent URL http://hdl.handle.net/10536/DRO/DU:30044125

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