Cancer targeted nanoparticles specifically induce apoptosis in cancer cells and spare normal cells

Kanwar, Jagat R., Kanwar, Rupinder K., Mahidhara, Ganesh and Cheung, Hei Chun Antonio 2012, Cancer targeted nanoparticles specifically induce apoptosis in cancer cells and spare normal cells, Australian journal of chemistry, vol. 65, no. 1, pp. 5-14.

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Title Cancer targeted nanoparticles specifically induce apoptosis in cancer cells and spare normal cells
Author(s) Kanwar, Jagat R.ORCID iD for Kanwar, Jagat R.
Kanwar, Rupinder K.
Mahidhara, Ganesh
Cheung, Hei Chun Antonio
Journal name Australian journal of chemistry
Volume number 65
Issue number 1
Start page 5
End page 14
Total pages 10
Publisher CSIRO
Place of publication Collingwood, VIC.
Publication date 2012
ISSN 0004-9425
Summary Curing cancer is the greatest challenge for modern medicine and finding ways to minimize the adverse effects caused by chemotherapeutic agents is of importance in improving patient’s physical conditions. Traditionally, chemotherapy can induce various adverse effects, and these effects are mostly caused by the non-target specific properties of the chemotherapeutic compounds. Recently, the use of nanoparticles has been found to be capable of minimizing these drug-induced adverse effects in animals and in patients during cancer treatment. The use of nanoparticles allows various chemotherapeutic drugs to be targeted to cancer cells with lower dosages. In addition to this, the use of nanoparticles also allows various drugs to be administered to the subjects by an oral route. Here, locked nucleic acid (LNA)-modified epithelial cell adhesion molecules (EpCAM), aptamers (RNA nucleotide), and nucleolin (DNA nucleotide) aptamers have been developed and conjugated on anti-cancer drug-loaded nanocarriers for specific delivery to cancer cells and spare normal cells. Significant amounts of the drug loaded nanocarriers (92 ± 6 %) were found to distribute to the cancer cells at the tumour site and more interestingly, normal cells were unaffected in vitro and in vivo. In this review, the benefits of using nanoparticle-coated drugs in various cancer treatments are discussed. Various nanoparticles that have been tried in improving the target specificity and potency of chemotherapeutic compounds are also described.
Language eng
Field of Research 100709 Nanomedicine
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2012, CSIRO
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