Individual differences predict susceptibility to conditioned fear arising from psychosocial trauma Walker, Frederick R., Hinwood, Madeleine, Masters, Louise, Dielenberg, Robert A. and Day, Trevor A. 2008, Individual differences predict susceptibility to conditioned fear arising from psychosocial trauma, Journal of psychiatric research, vol. 42, no. 5, pp. 371-383, doi: 10.1016/j.jpsychires.2007.01.007. Attached Files Name Description MIMEType Size Downloads Title Individual differences predict susceptibility to conditioned fear arising from psychosocial trauma Author(s) Walker, Frederick R. Hinwood, Madeleine Masters, Louise Dielenberg, Robert A. Day, Trevor A. Journal name Journal of psychiatric research Volume number 42 Issue number 5 Start page 371 End page 383 Total pages 13 Publisher Elsevier Place of publication Amsterdam, The Netherlands Publication date 2008-04 ISSN 0022-3956 Keyword(s) fear individual differences trauma conditioned fear PTSD social conflict Summary Background : Classical Pavlovian fear conditioning has been widely used in preclinical studies to gain insights into anxiety-related disorders. In this study we examined whether pre-existing behavioral differences, and/or behavioral differences displayed during fear induction, predict the severity of the conditioned fear response that can develop after an episode of psychosocial conflict. Methods : Prior to conditioning, male rats (intruders) were behaviorally assessed using the novel environment exploration and defensive burying tests. These animals were subsequently placed in the territory of an older male (resident) that invariably attacked the intruder. Results : Upon return to this territory 24 h later, intruders moved less than controls and produced more distress vocalizations, indicating conditioned fear to context. Additionally, analyses revealed that both pre-existing behavioral differences, and the animal’s response during social conflict, predicted the magnitude of the subsequent conditioned fear response. Specifically, animals that engaged in higher levels of novel environment exploration, that exhibited a greater number of defensive burying behaviors, and that demonstrated higher levels of fighting and guarding during social conflict, displayed less evidence of conditioned fear. Conclusion : These findings show that the behavioral variability existent within a normal outbred population can predict the magnitude of the conditioned fear response. Language eng DOI 10.1016/j.jpsychires.2007.01.007 Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences HERDC Research category C1.1 Refereed article in a scholarly journal Copyright notice ©2007, Elsevier Persistent URL http://hdl.handle.net/10536/DRO/DU:30044496 Document type: Journal Article Collection: Faculty of Science, Engineering and Built Environment Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Thu, 19 Apr 2012, 10:26:51 EST Thu, 26 Apr 2012, 11:00:56 EST Thu, 26 Apr 2012, 11:04:14 EST Mon, 30 Apr 2012, 08:52:20 EST Mon, 07 May 2012, 10:29:44 EST Thu, 11 Dec 2014, 17:46:40 EST Filtered Full Citation counts:   Cited 20 times in TR Web of Science Cited 22 times in Scopus Search Google Scholar Access Statistics: 494 Abstract Views, 2 File Downloads  -  Detailed Statistics Created: Thu, 19 Apr 2012, 10:26:51 EST