Respiratory pattern in awake rats : effects of motor activity and of alerting stimuli Kabir, Muammar M., Beig, Mirza I., Baumert, Mathias, Trombini, Mimosa, Mastorci, Francesca, Sgoifo, Andrea, Walker, Frederick R., Day, Trevor A. and Nalivaiko, Eugene 2010, Respiratory pattern in awake rats : effects of motor activity and of alerting stimuli, Physiology & behavior, vol. 101, no. 1, pp. 22-31, doi: 10.1016/j.physbeh.2010.04.004. Attached Files Name Description MIMEType Size Downloads Title Respiratory pattern in awake rats : effects of motor activity and of alerting stimuli Author(s) Kabir, Muammar M. Beig, Mirza I. Baumert, Mathias Trombini, Mimosa Mastorci, Francesca Sgoifo, Andrea Walker, Frederick R. Day, Trevor A. Nalivaiko, Eugene Journal name Physiology & behavior Volume number 101 Issue number 1 Start page 22 End page 31 Total pages 10 Publisher Elsevier Place of publication Amsterdam, The Netherlands Publication date 2010-08-04 ISSN 0031-9384 1873-507X Keyword(s) 0031-9384 respiratory rate motor activity arousal Summary Our aim was to assess the impact of motor activity and of arousing stimuli on respiratory rate in the awake rats. The study was performed in male adult Sprague–Dawley (SD, n = 5) and Hooded Wistar (HW, n = 5) rats instrumented for ECG telemetry. Respiratory rate was recorded using whole-body plethysmograph, with a piezoelectric sensor attached for the simultaneous assessment of motor activity. All motor activity was found to be associated with an immediate increase in respiratory rate that remained elevated for the whole duration of movement; this was reflected by: i) bimodal distribution of respiratory intervals (modes for slow peak: 336 ± 19 and 532 ± 80 ms for HW and SD, p < 0.05; modes for fast peak 128 ± 6 and 132 ± 7 ms for HW and SD, NS); and ii) a tight correlation between total movement time and total time of tachypnoea, with an R2 ranging 0.96–0.99 (n = 10, p < 0001). The extent of motor-related tachypnoea was significantly correlated with the intensity of associated movement. Mild alerting stimuli produced stereotyped tachypnoeic responses, without affecting heart rate: tapping the chamber raised respiratory rate from 117 ± 7 to 430 ± 15 cpm; sudden side move — from 134 ± 13 to 487 ± 16 cpm, and turning on lights — from 136 ± 12 to 507 ± 14 cpm (n = 10; p < 0.01 for all; no inter-strain differences). We conclude that: i) sniffing is an integral part of the generalized arousal response and does not depend on the modality of sensory stimuli; ii) tachypnoea is a sensitive index of arousal; and iii) respiratory rate is tightly correlated with motor activity. Language eng DOI 10.1016/j.physbeh.2010.04.004 Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences HERDC Research category C1.1 Refereed article in a scholarly journal Copyright notice ©2010, Elsevier Persistent URL http://hdl.handle.net/10536/DRO/DU:30044505 Document type: Journal Article Collection: Faculty of Science, Engineering and Built Environment Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Thu, 19 Apr 2012, 10:27:11 EST Fri, 27 Apr 2012, 10:57:27 EST Fri, 27 Apr 2012, 10:58:45 EST Mon, 07 May 2012, 10:41:03 EST Fri, 11 May 2012, 09:44:03 EST Thu, 11 Dec 2014, 17:46:51 EST Filtered Full Citation counts:   Cited 57 times in TR Web of Science Cited 57 times in Scopus Search Google Scholar Access Statistics: 500 Abstract Views, 1 File Downloads  -  Detailed Statistics Created: Thu, 19 Apr 2012, 10:27:11 EST