Strain differences in coping behaviour, novelty seeking behaviour, and susceptibility to socially conditioned fear : a comparison between Wistar and Sprague Dawley rats Walker, Frederick R., Naicker, Sundresan, Hinwood, Madeleine, Dunn, Nicole and Day, Trevor A. 2009, Strain differences in coping behaviour, novelty seeking behaviour, and susceptibility to socially conditioned fear : a comparison between Wistar and Sprague Dawley rats, Stress, vol. 12, no. 6, pp. 507-516, doi: 10.3109/10253890802673134. Attached Files Name Description MIMEType Size Downloads Title Strain differences in coping behaviour, novelty seeking behaviour, and susceptibility to socially conditioned fear : a comparison between Wistar and Sprague Dawley rats Author(s) Walker, Frederick R. Naicker, Sundresan Hinwood, Madeleine Dunn, Nicole Day, Trevor A. Journal name Stress Volume number 12 Issue number 6 Start page 507 End page 516 Total pages 10 Publisher Informa Healthcare Place of publication London, England Publication date 2009-11 ISSN 1025-3890 Keyword(s) active coping conditioned fear novelty seeking social conflict social defeat social stress Summary The aim of the current study was to generate socially conditioned fear in two different strains of rat (Wistar, W and Sprague Dawley, SD) using social conflict, in order to investigate whether the magnitude of the conditioned fear responses in each strain was related to behaviour exhibited prior to or during fear induction (i.e. social conflict). On day one of the study, all intruders were assessed for exploratory activity in a novel environment. Twenty four hours following the novel environment test the locomotor activity of the intruders was assessed, while they underwent a single familiarisation exposure to the arena in which the conflict was subsequently to occur in. Twenty-four hours following familiarisation, intruders underwent either a 10 min social conflict or sham conflict session. One day later we examined the response of the intruders when they were returned to the vacant resident's cage. Upon return to the conflict context, we examined the intruder's ultrasonic distress vocalisations and the extent to which locomotor activity was inhibited. We found that W rats displayed significantly more immobility (i.e. conditioned fear) upon return to context than did SD rats (p < 0.05). Importantly, we observed that the differences in the two strains behaviour upon return to context appeared to be related to their quite different patterns of coping behaviour. The results of the current study indicate that preclinical between-strain comparisons potentially have much to offer in regard to understanding the basis of resilience to social stress. Language eng DOI 10.3109/10253890802673134 Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences HERDC Research category C1.1 Refereed article in a scholarly journal Copyright notice ©2009, Informa Healthcare Persistent URL http://hdl.handle.net/10536/DRO/DU:30044507 Document type: Journal Article Collection: Faculty of Science, Engineering and Built Environment Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Thu, 19 Apr 2012, 10:27:15 EST Fri, 27 Apr 2012, 10:05:44 EST Fri, 27 Apr 2012, 10:13:20 EST Mon, 07 May 2012, 10:46:36 EST Thu, 11 Dec 2014, 17:46:55 EST Filtered Full Citation counts:   Cited 14 times in TR Web of Science Cited 15 times in Scopus Search Google Scholar Access Statistics: 501 Abstract Views, 1 File Downloads  -  Detailed Statistics Created: Thu, 19 Apr 2012, 10:27:15 EST