Direct methods for distinction between endogenous and exogenous erythropoietin

Lamon, Séverine, Robinson, Neil and Saugy, Martial 2011, Direct methods for distinction between endogenous and exogenous erythropoietin. In Ghigo, Ezio, Lanfranco, Fabio and Strasburger, Christian J. (ed), Hormone use and abuse by athletes, Springer, New York, N. Y., pp.163-175, doi: 10.1007/978-1-4419-7014-5_17.

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Title Direct methods for distinction between endogenous and exogenous erythropoietin
Author(s) Lamon, SéverineORCID iD for Lamon, Séverine
Robinson, Neil
Saugy, Martial
Title of book Hormone use and abuse by athletes
Editor(s) Ghigo, Ezio
Lanfranco, Fabio
Strasburger, Christian J.
Publication date 2011
Series Endocrine updates
Chapter number 17
Total chapters 17
Start page 163
End page 175
Total pages 13
Publisher Springer
Place of Publication New York, N. Y.
Keyword(s) anti-doping
artificial performance enhancer
blood doping
Summary Since the commercialization of the first recombinant human erythropoietin (rhEPO) product (epoetin-a) in 1989 as a treatment for acute anemia, rhEPO detection has represented a continuous challenge for the anti-doping fight. Indeed, it appeared rapidly that this ergogenic hormone would be abused by athletes looking for an artificial performance enhancer. Hemoglobin is one of the principal modulators of aerobic power [1, 2] and, consequently, of performance in endurance sports [3]. By stimulating the red blood cells production, EPO is known to raise hemoglobin concentration in a dose-dependant and predictable way. Therefore, this hormone soon became one of the athletes most popular doping agent. Since 1984, all forms of blood doping in sport have been officially banned. In 1990, the IOC medical commission, which was in charge of the anti-doping regulations, added rhEPO to the list of the prohibited drugs in sports, even if a direct test allowing to detect the molecule became available a decade after only.
ISBN 1441970134
Language eng
DOI 10.1007/978-1-4419-7014-5_17
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category B1.1 Book chapter
Copyright notice ©2011, Springer Science+Business Media, LLC
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