Total antioxidant status correlates with cognitive impairment in patients with recurrent depressive disorder

Talarowska, Monika, Galecki, Piotr, Maes, Michael, Bobinska, Kinga and Kowalczyk, Edward 2012, Total antioxidant status correlates with cognitive impairment in patients with recurrent depressive disorder, Neurochemical research, vol. 37, no. 8, pp. 1761-1767, doi: 10.1007/s11064-012-0788-z.

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Title Total antioxidant status correlates with cognitive impairment in patients with recurrent depressive disorder
Author(s) Talarowska, Monika
Galecki, Piotr
Maes, Michael
Bobinska, Kinga
Kowalczyk, Edward
Journal name Neurochemical research
Volume number 37
Issue number 8
Start page 1761
End page 1767
Total pages 7
Publisher Springer New York LLC
Place of publication New York, N. Y.
Publication date 2012-08
ISSN 0364-3190
Keyword(s) depression
total antioxidant status
cognitive impairment
Summary Depressive disorder is a multifactorial diseases, that one of the typical feature are cognitive impairments. The aim of this study was to determine the total antioxidant status (TAS) in patients with recurrent depressive disorder (rDD) and to define relationship between plasma levels of TAS and the cognitive performance. Design and methods: the study comprised 74 subjects: patients with rDD (n = 45) and healthy subjects (n = 29). Cognitive function assessment was based on: Trail Making Test, The Stroop Test, Verbal Fluency Test and Auditory Verbal Learning Test. Statistically significant differences were found in the intensity of depression symptoms, measured by the Hamilton Depression Rating Scale (HDRS) on therapy onset versus the examination results after 8 weeks of treatment (p < 0.001). The level of TAS was substantially higher in patients with rDD (p = 0.01). For rDD patients, elevated TAS levels were associated with worse cognitive test performance. The higher was the concentration of plasma TAS, the greater was the severity of depressive symptoms measured by HDRS before and after pharmacotherapy. (1) Higher concentration of plasma TAS in rDD patients is associated with the severity of depressive symptoms. (2) Elevated levels of plasma TAS are related to impairment of short-term declarative memory, long-term declarative-memory, verbal fluency and working memory.
Language eng
DOI 10.1007/s11064-012-0788-z
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2012, Springer Science+Business Media, LLC
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