Gender-common and -specific neuroanatomical basis of human anxiety-related personality traits

Yamasue, Hidenori, Abe, Osamu, Suga, Motomu, Yamada, Haruyasu, Inoue, Hideyuki, Tochigi, Mamoru, Rogers, Mark, Aoki, Shigeki, Kato, Nobumasa and Kasai, Kiyoto 2008, Gender-common and -specific neuroanatomical basis of human anxiety-related personality traits, Cerebral cortex, vol. 18, no. 1, pp. 46-52, doi: 10.1093/cercor/bhm030.

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Title Gender-common and -specific neuroanatomical basis of human anxiety-related personality traits
Author(s) Yamasue, Hidenori
Abe, Osamu
Suga, Motomu
Yamada, Haruyasu
Inoue, Hideyuki
Tochigi, Mamoru
Rogers, MarkORCID iD for Rogers, Mark orcid.org/0000-0002-6808-9545
Aoki, Shigeki
Kato, Nobumasa
Kasai, Kiyoto
Journal name Cerebral cortex
Volume number 18
Issue number 1
Start page 46
End page 52
Total pages 7
Publisher Oxford University Press
Place of publication Oxford, England
Publication date 2008-01
ISSN 1047-3211
1460-2199
Keyword(s) anxiety
gender
hippocampus
MRI
prefrontal cortex
Summary Exploration of the relationships between regional brain volume and anxiety-related personality traits is important for understanding preexisting vulnerability to depressive and anxiety disorders. However, previous studies on this topic have employed relatively limited sample sizes and/or image processing methodology, and they have not clarified possible gender differences. In the present study, 183 (male/female: 117/66) right-handed healthy individuals in the third and fourth decades of life underwent structural magnetic resonance imaging scans and Temperament and Character Inventory. Neuroanatomical correlates of individual differences in the score of harm avoidance (HA) were examined throughout the entire brain using voxel-based morphometry. We found that higher scores on HA were associated with smaller regional gray matter volume in the right hippocampus, which was common to both genders. In contrast, female-specific correlation was found between higher anxiety-related personality traits and smaller regional brain volume in the left anterior prefrontal cortex. The present findings suggest that smaller right hippocampal volume underlies the basis for higher anxiety-related traits common to both genders, whereas anterior prefrontal volume contributes only in females. The results may have implications for why susceptibility to stress-related disorders such as anxiety disorders and depression shows gender and/or individual differences.
Language eng
DOI 10.1093/cercor/bhm030
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2007, The Author
Persistent URL http://hdl.handle.net/10536/DRO/DU:30047633

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
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