Primary systemic therapy in HER2-amplified breast cancer : a clinical review

Khasraw, Mustafa and Bell, Richard 2012, Primary systemic therapy in HER2-amplified breast cancer : a clinical review, Expert review of anticancer therapy, vol. 12, no. 8, pp. 1005-1013, doi: 10.1586/era.12.62.

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Title Primary systemic therapy in HER2-amplified breast cancer : a clinical review
Author(s) Khasraw, MustafaORCID iD for Khasraw, Mustafa
Bell, Richard
Journal name Expert review of anticancer therapy
Volume number 12
Issue number 8
Start page 1005
End page 1013
Total pages 9
Publisher Expert Reviews
Place of publication London, England
Publication date 2012
ISSN 1473-7140
Keyword(s) HER2-positive breat cancer
neoadjuvant chemotherapy
primary systemic therapy
Summary Primary systemic therapy (PST) in early breast cancer is utilized in locally advanced breast tumors and when breast-conserving surgery is desirable. In addition, the PST setting provides an opportunity to monitor response including histopathological and biomarker examination of the tumor and host tissues before and after systemic therapy. Trastuzumab is a monoclonal antibody targeting the hEGF receptor that is overexpressed in 15–20% of breast tumors. Trastuzumab is effective in prolonging survival when used to treat women with hEGF receptor overexpressed tumors, both in adjuvant and metastatic disease settings. Trastuzumab has also shown promising activity in PST/neoadjuvant studies by achieving high rates of complete pathologic response. This is a review of clinical studies that incorporated trastuzumab in PST and/or neoadjuvant chemotherapy, including the results of recently reported studies using trastuzumab in combination with other novel therapies such as lapatinib or pertuzumab.
Language eng
DOI 10.1586/era.12.62
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2012, Expert Reviews
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Document type: Journal Article
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School of Medicine
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