The regulation and function of the striated muscle activator of rho signaling (STARS) protein Wallace, Marita A., Lamon, Severine and Russell, Aaron P. 2012, The regulation and function of the striated muscle activator of rho signaling (STARS) protein, Frontiers in physiology, vol. 3, no. Article 469, pp. 1-5, doi: 10.3389/fphys.2012.00469. Attached Files Name Description MIMEType Size Downloads wallace-theregulation-2012.pdf Published version application/pdf 589.70KB 188 Title The regulation and function of the striated muscle activator of rho signaling (STARS) protein Author(s) Wallace, Marita A. Lamon, Severine orcid.org/0000-0002-3271-6551 Russell, Aaron P. orcid.org/0000-0002-7323-9501 Journal name Frontiers in physiology Volume number 3 Issue number Article 469 Start page 1 End page 5 Total pages 5 Publisher Frontiers Research Foundation Place of publication Lausanne, Switzerland Publication date 2012-12 ISSN 1664-042X 1664-1078 Keyword(s) ABRA smooth muscle skeletal muscle cardiac muscle disuse exercise sarcomere MS-1 Summary Healthy living throughout the lifespan requires continual growth and repair of cardiac, smooth, and skeletal muscle. To effectively maintain these processes muscle cells detect extracellular stress signals and efficiently transmit them to activate appropriate intracellular transcriptional programs. The striated muscle activator of Rho signaling (STARS) protein, also known as Myocyte Stress-1 (MS1) protein and Actin-binding Rho-activating protein (ABRA) is highly enriched in cardiac, skeletal, and smooth muscle. STARS binds actin, co-localizes to the sarcomere and is able to stabilize the actin cytoskeleton. By regulating actin polymerization, STARS also controls an intracellular signaling cascade that stimulates the serum response factor (SRF) transcriptional pathway; a pathway controlling genes involved in muscle cell proliferation, differentiation, and growth. Understanding the activation, transcriptional control and biological roles of STARS in cardiac, smooth, and skeletal muscle, will improve our understanding of physiological and pathophysiological muscle development and function. Language eng DOI 10.3389/fphys.2012.00469 Field of Research 111603 Systems Physiology Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2012, Frontiers Research Foundation Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30050073 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Open Access Collection Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Mon, 14 Jan 2013, 13:41:15 EST Tue, 15 Jan 2013, 14:14:15 EST Tue, 15 Jan 2013, 14:17:01 EST Tue, 15 Jan 2013, 14:18:09 EST Tue, 10 Dec 2013, 14:35:25 EST Fri, 13 Jun 2014, 16:23:10 EST Wed, 02 Jul 2014, 15:58:26 EST Tue, 03 Feb 2015, 13:20:36 EST Thu, 05 Mar 2015, 14:07:15 EST Tue, 06 Sep 2016, 20:19:29 EST Tue, 05 Dec 2017, 12:38:35 EST Fri, 07 Sep 2018, 16:22:03 EST Filtered Full Citation counts:   Cited 17 times in TR Web of Science Cited 18 times in Scopus Search Google Scholar Access Statistics: 695 Abstract Views, 188 File Downloads  -  Detailed Statistics Created: Mon, 14 Jan 2013, 13:41:03 EST by Jane Moschetti