Using lithium as a neuroprotective agent in patients with cancer Khasraw, Mustafa, Ashley, David, Wheeler, Greg and Berk, Michael 2012, Using lithium as a neuroprotective agent in patients with cancer, BMC Medicine, vol. 10, no. 131, pp. 1-7, doi: 10.1186/1741-7015-10-131. Attached Files Name Description MIMEType Size Downloads khasraw-usinglithium-2012.pdf Published version application/pdf 304.42KB 359 Title Using lithium as a neuroprotective agent in patients with cancer Author(s) Khasraw, Mustafa orcid.org/0000-0003-3249-9849 Ashley, David Wheeler, Greg Berk, Michael orcid.org/0000-0002-5554-6946 Journal name BMC Medicine Volume number 10 Issue number 131 Start page 1 End page 7 Total pages 7 Publisher BioMed Central Place of publication London, England Publication date 2012-11-02 ISSN 1741-7015 Keyword(s) acute lymphoblastic leukemia Alzheimer disease bipolar disorder brain disease brain metastasis brain radiation brain tumor cancer chemotherapy cancer patient cancer radiotherapy Summary Neurocognitive impairment is being increasingly recognized as an important issue in patients with cancer who develop cognitive difficulties either as part of direct or indirect involvement of the nervous system or as a consequence of either chemotherapy-related or radiotherapy-related complications. Brain radiotherapy in particular can lead to significant cognitive defects. Neurocognitive decline adversely affects quality of life, meaningful employment, and even simple daily activities. Neuroprotection may be a viable and realistic goal in preventing neurocognitive sequelae in these patients, especially in the setting of cranial irradiation. Lithium is an agent that has been in use for psychiatric disorders for decades, but recently there has been emerging evidence that it can have a neuroprotective effect. This review discusses neurocognitive impairment in patients with cancer and the potential for investigating the use of lithium as a neuroprotectant in such patients. Notes This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Language eng DOI 10.1186/1741-7015-10-131 Field of Research 110999 Neurosciences not elsewhere classified Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2012, Khasraw et al. Free to Read? Yes Use Rights Persistent URL http://hdl.handle.net/10536/DRO/DU:30050134 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Mon, 21 Jan 2013, 11:11:12 EST Tue, 22 Jan 2013, 09:51:05 EST Tue, 22 Jan 2013, 09:56:13 EST Tue, 22 Jan 2013, 09:56:56 EST Wed, 21 Oct 2015, 17:56:58 EST Fri, 26 Aug 2016, 15:02:13 EST Mon, 05 Sep 2016, 15:47:24 EST Fri, 07 Sep 2018, 12:00:33 EST Filtered Full Citation counts:   Cited 29 times in TR Web of Science Cited 31 times in Scopus Search Google Scholar Access Statistics: 1038 Abstract Views, 359 File Downloads  -  Detailed Statistics Created: Mon, 21 Jan 2013, 11:10:59 EST by Jane Moschetti