The effect of obesity on polycystic ovary syndrome : a systematic review and meta-analysis

Lim, S. S., Norman, R. J., Davies, M. J. and Moran, L. J. 2013, The effect of obesity on polycystic ovary syndrome : a systematic review and meta-analysis, Obesity reviews, vol. 14, no. 2, pp. 95-109, doi: 10.1111/j.1467-789X.2012.01053.x.

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Title The effect of obesity on polycystic ovary syndrome : a systematic review and meta-analysis
Author(s) Lim, S. S.ORCID iD for Lim, S. S.
Norman, R. J.
Davies, M. J.
Moran, L. J.
Journal name Obesity reviews
Volume number 14
Issue number 2
Start page 95
End page 109
Total pages 15
Publisher Wiley - Blackwell Publishing
Place of publication Chichester, England
Publication date 2013-02
ISSN 1467-7881
Keyword(s) central obesity
polycystic ovary syndrome
Summary While many women with polycystic ovary syndrome (PCOS) are overweight, obese or centrally obese, the effect of excess weight on the outcomes of PCOS is inconsistent. The review aimed to assess the effects of overweight, obesity and central obesity on the reproductive, metabolic and psychological features of PCOS. MEDLINE, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials (CENTRAL) and PSYCINFO were searched for studies reporting outcomes according to body mass index categories or body fat distribution. Data were presented as mean difference or risk ratio (95% confidence interval). This review included 30 eligible studies. Overweight or obese women with PCOS had decreased sex hormone-binding globulin (SHBG), increased total testosterone, free androgen index, hirsutism, fasting glucose, fasting insulin, homeostatic model assessment-insulin resistance index and worsened lipid profile. Obesity significantly worsened all metabolic and reproductive outcomes measured except for hirsutism when compared to normal weight women with PCOS. Overweight women had no differences in total testosterone, hirsutism, total-cholesterol and low-density lipoprotein-cholesterol compared to normal weight women and no differences in SHBG and total testosterone compared to obese women. Central obesity was associated with higher fasting insulin levels. These results suggest that prevention and treatment of obesity is important for the management of PCOS.
Language eng
DOI 10.1111/j.1467-789X.2012.01053.x
Field of Research 111717 Primary Health Care
Socio Economic Objective 920104 Diabetes
HERDC Research category C1 Refereed article in a scholarly journal
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Document type: Journal Article
Collections: Faculty of Health
Population Health
PVC's Office - Health
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