Hypothalamic gene expression in w-3 PUFA-deficient male rats before, and following, development of hypertension Begg, Denovan P., Puskas, Laszlo G., Kitajka, Klara, Menesi, Dalma, Allen, Andrew M., Li, Duo, Mathai, Michael L., Shi, Jian R., Sinclair, Andrew J. and Weisinger, Richard S. 2012, Hypothalamic gene expression in w-3 PUFA-deficient male rats before, and following, development of hypertension, Hypertension research, vol. 35, no. 4, pp. 381-387, doi: 10.1038/hr.2011.194. Attached Files Name Description MIMEType Size Downloads Title Hypothalamic gene expression in w-3 PUFA-deficient male rats before, and following, development of hypertension Author(s) Begg, Denovan P. Puskas, Laszlo G. Kitajka, Klara Menesi, Dalma Allen, Andrew M. Li, Duo Mathai, Michael L. Shi, Jian R. Sinclair, Andrew J. Weisinger, Richard S. Journal name Hypertension research Volume number 35 Issue number 4 Start page 381 End page 387 Total pages 7 Publisher Nature Publishing Group Place of publication London, England Publication date 2012-04 ISSN 0916-9636 1348-4214 Keyword(s) adrenergic angiotensin gene expression ω-3 fatty acids Summary Dietary deficiency of ω-3 fatty acids (ω-3 DEF) produces hypertension in later life. This study examined the effect of ω-3 DEF on blood pressure and hypothalamic gene expression in young rats, before the development of hypertension, and in older rats following the onset of hypertension. Animals were fed experimental diets that were deficient in ω-3 fatty acids, sufficient in short-chain ω-3 fatty acids or sufficient in short- and long-chain ω-3 fatty acids, from the prenatal period until 10 or 36 weeks-of-age. There was no difference in blood pressure between groups at 10 weeks-of-age; however, at 36 weeks-of-age ω-3 DEF animals were hypertensive in relation to sufficient groups. At 10 weeks, expression of angiotensin-II1A receptors and dopamine D3 receptors were significantly increased in the hypothalamic tissue of ω-3 DEF animals. In contrast, at 36 weeks, α2a and β1 adrenergic receptor expression was significantly reduced in the ω-3 DEF group. Brain docosahexaenoic acid was significantly lower in ω-3 DEF group compared with sufficient groups. This study demonstrates that dietary ω-3 DEF causes changes both in the expression of key genes involved in central blood pressure regulation and in blood pressure. The data may indicate that hypertension resulting from ω-3 DEF is mediated by the central adrenergic system. Language eng DOI 10.1038/hr.2011.194 Field of Research 111103 Nutritional Physiology Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1 Refereed article in a scholarly journal Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30050697 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Related Links Link Description Link to full-text (open access)   Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Tue, 19 Feb 2013, 13:23:16 EST Tue, 19 Feb 2013, 13:30:23 EST Wed, 27 Feb 2013, 10:06:29 EST Wed, 27 Feb 2013, 10:11:08 EST Fri, 08 Nov 2019, 14:39:26 EST Filtered Full Citation counts:   Cited 14 times in TR Web of Science Cited 13 times in Scopus Search Google Scholar Access Statistics: 665 Abstract Views, 2 File Downloads  -  Detailed Statistics Created: Tue, 19 Feb 2013, 13:23:15 EST by Jane Moschetti