Biomarkers in bipolar disorder : a positional paper from the International Society for Bipolar Disorders Biomarkers Task Force

Frey, Benicio N., Andreazza, Ana C., Houenou, Josselin, Jamain, Stephane, Goldstein, Benjamin, Frye, Mark A., Leboyer, Marion, Berk, Michael, Malhi, Gin S., Lopez-Jaramillo, Carlos, Taylor, Valerie H., Dodd, Seetal, Frangou, Sophia, Hall, Geoffrey B., Fernandes, Brisa S., Kauer-Sant'Anna, Marcia, Yatham, Lakshmi N., Kapczinski, Flavio and Young, L. Trevor 2013, Biomarkers in bipolar disorder : a positional paper from the International Society for Bipolar Disorders Biomarkers Task Force, Australian and New Zealand journal of psychiatry, vol. 47, no. 4, pp. 321-332, doi: 10.1177/0004867413478217.

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Title Biomarkers in bipolar disorder : a positional paper from the International Society for Bipolar Disorders Biomarkers Task Force
Author(s) Frey, Benicio N.
Andreazza, Ana C.
Houenou, Josselin
Jamain, Stephane
Goldstein, Benjamin
Frye, Mark A.
Leboyer, Marion
Berk, MichaelORCID iD for Berk, Michael
Malhi, Gin S.
Lopez-Jaramillo, Carlos
Taylor, Valerie H.
Dodd, SeetalORCID iD for Dodd, Seetal
Frangou, Sophia
Hall, Geoffrey B.
Fernandes, Brisa S.
Kauer-Sant'Anna, Marcia
Yatham, Lakshmi N.
Kapczinski, Flavio
Young, L. Trevor
Journal name Australian and New Zealand journal of psychiatry
Volume number 47
Issue number 4
Start page 321
End page 332
Total pages 12
Publisher Sage Publications
Place of publication London, England
Publication date 2013
ISSN 0004-8674
Keyword(s) biomarkers
bipolar disorder
oxidative stress
Summary Although the etiology of bipolar disorder remains uncertain, multiple studies examining neuroimaging, peripheral markers and genetics have provided important insights into the pathophysiologic processes underlying bipolar disorder. Neuroimaging studies have consistently demonstrated loss of gray matter, as well as altered activation of subcortical, anterior temporal and ventral prefrontal regions in response to emotional stimuli in bipolar disorder. Genetics studies have identified several potential candidate genes associated with increased risk for developing bipolar disorder that involve circadian rhythm, neuronal development and calcium metabolism. Notably, several groups have found decreased levels of neurotrophic factors and increased pro-inflammatory cytokines and oxidative stress markers. Together these findings provide the background for the identification of potential biomarkers for vulnerability, disease expression and to help understand the course of illness and treatment response. In other areas of medicine, validated biomarkers now inform clinical decision-making. Although the findings reviewed herein hold promise, further research involving large collaborative studies is needed to validate these potential biomarkers prior to employing them for clinical purposes. Therefore, in this positional paper from the ISBD-BIONET (biomarkers network from the International Society for Bipolar Disorders), we will discuss our view of biomarkers for these three areas: neuroimaging, peripheral measurements and genetics; and conclude the paper with our position for the next steps in the search for biomarkers for bipolar disorder.
Language eng
DOI 10.1177/0004867413478217
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Grant ID NHMRC 1026265
Persistent URL

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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