Host defense at the ocular surface

Pearlman, Eric, Sun, Yan, Roy, Sanhita, Karmakar, Mausita, Hise, Amy G., Szcotka-Flynn, Loretta, Ghannoum, Mahmoud, Chinnery, Holly R., McMenamin, Paul G. and Rietsch, Arne 2013, Host defense at the ocular surface, International reviews of immunology, vol. 32, no. 1, pp. 4-18, doi: 10.3109/08830185.2012.749400.

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Title Host defense at the ocular surface
Author(s) Pearlman, Eric
Sun, Yan
Roy, Sanhita
Karmakar, Mausita
Hise, Amy G.
Szcotka-Flynn, Loretta
Ghannoum, Mahmoud
Chinnery, Holly R.
McMenamin, Paul G.
Rietsch, Arne
Journal name International reviews of immunology
Volume number 32
Issue number 1
Start page 4
End page 18
Total pages 15
Publisher Informa Healthcare
Place of publication London, England
Publication date 2013-02
ISSN 0883-0185
Keyword(s) bacterial
epithelial cells
pseudomonas aeruginosa
toll-like receptors
Summary Microbial infections of the cornea frequently cause painful, blinding and debilitating disease that is often difficult to treat and may require corneal transplantation. In addition, sterile corneal infiltrates that are associated with contact lens wear cause pain, visual impairment and photophobia. In this article, we review the role of Toll-Like Receptors (TLR) in bacterial keratitis and sterile corneal infiltrates, and describe the role of MD-2 regulation in LPS responsiveness by corneal epithelial cells. We conclude that both live bacteria and bacterial products activate Toll-Like Receptors in the cornea, which leads to chemokine production and neutrophil recruitment to the corneal stroma. While neutrophils are essential for bacterial killing, they also cause tissue damage that results in loss of corneal clarity. These disparate outcomes, therefore, represent a spectrum of disease severity based on this pathway, and further indicate that targeting the TLR pathway is a feasible approach to treating inflammation caused by live bacteria and microbial products. Further, as the P. aeruginosa type III secretion system (T3SS) also plays a critical role in disease pathogenesis by inducing neutrophil apoptosis and facilitating bacterial growth in the cornea, T3SS exotoxins are additional targets for therapy for P. aeruginosa keratitis.
Language eng
DOI 10.3109/08830185.2012.749400
Field of Research 110707 Innate Immunity
Socio Economic Objective 920108 Immune System and Allergy
HERDC Research category C1 Refereed article in a scholarly journal
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Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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