A preliminary investigation on the efficacy of N-acetyl cysteine for mania or hypomania
Vieira da Silva Magalhaes, Pedro, Dean, Olivia, Bush, Ashley I., Copolov, David L., Malhi, Gin S., Kohlmann, Kristy, Jeavons, Susan, Schapkaitz, Ian, Anderson-Hunt, Murray and Berk, Michael 2013, A preliminary investigation on the efficacy of N-acetyl cysteine for mania or hypomania, Australian and New Zealand journal of psychiatry, vol. 47, no. 6, pp. 564-568, doi: 10.1177/0004867413481631.
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A preliminary investigation on the efficacy of N-acetyl cysteine for mania or hypomania
Objective: Oxidative imbalance has emerged as a treatment target in bipolar disorder. As very limited data are available on the clinical use of antioxidants for mania, we report here results from a post hoc and exploratory subgroup analysis of a randomized, placebo-controlled trial of N-acetyl cysteine (NAC).
Methods: This was a placebo-controlled, randomized, clinical trial assessing the effect of NAC over 24 weeks in mania or hypomania. Symptomatic and functional outcomes were collected over the study period. Results: Fifteen participants were available for this report; two participants in each group failed to complete all assessments. Within-group analyses pointed to an improvement in the NAC group on manic symptoms and worsening in the placebo group on depressive symptoms at endpoint. Conclusions: Although the sample size was small, these results indicated within-group efficacy for this glutathione precursor as compared to placebo. Future trials specifically designed to demonstrate the efficacy of NAC in mania are needed.
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