A preliminary investigation on the efficacy of N-acetyl cysteine for mania or hypomania

Vieira da Silva Magalhaes, Pedro, Dean, Olivia, Bush, Ashley I., Copolov, David L., Malhi, Gin S., Kohlmann, Kristy, Jeavons, Susan, Schapkaitz, Ian, Anderson-Hunt, Murray and Berk, Michael 2013, A preliminary investigation on the efficacy of N-acetyl cysteine for mania or hypomania, Australian and New Zealand journal of psychiatry, vol. 47, no. 6, pp. 564-568, doi: 10.1177/0004867413481631.

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Title A preliminary investigation on the efficacy of N-acetyl cysteine for mania or hypomania
Author(s) Vieira da Silva Magalhaes, Pedro
Dean, OliviaORCID iD for Dean, Olivia orcid.org/0000-0002-2776-3935
Bush, Ashley I.
Copolov, David L.
Malhi, Gin S.
Kohlmann, Kristy
Jeavons, Susan
Schapkaitz, Ian
Anderson-Hunt, Murray
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Journal name Australian and New Zealand journal of psychiatry
Volume number 47
Issue number 6
Start page 564
End page 568
Total pages 5
Publisher Sage Publications
Place of publication London, England
Publication date 2013-06
ISSN 0004-8674
Keyword(s) Bipolar disorder
N-acetyl cysteine
oxidative stress
Summary Objective: Oxidative imbalance has emerged as a treatment target in bipolar disorder. As very limited data are available on the clinical use of antioxidants for mania, we report here results from a post hoc and exploratory subgroup analysis of a randomized, placebo-controlled trial of N-acetyl cysteine (NAC).

Methods: This was a placebo-controlled, randomized, clinical trial assessing the effect of NAC over 24 weeks in mania or hypomania. Symptomatic and functional outcomes were collected over the study period.

Fifteen participants were available for this report; two participants in each group failed to complete all assessments. Within-group analyses pointed to an improvement in the NAC group on manic symptoms and worsening in the placebo group on depressive symptoms at endpoint.

Although the sample size was small, these results indicated within-group efficacy for this glutathione precursor as compared to placebo. Future trials specifically designed to demonstrate the efficacy of NAC in mania are needed.
Language eng
DOI 10.1177/0004867413481631
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Grant ID NHMRC 1026307
Copyright notice ©2013, Sage Publishing
Persistent URL http://hdl.handle.net/10536/DRO/DU:30052815

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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