A preliminary investigation on the efficacy of N-acetyl cysteine for mania or hypomania Vieira da Silva Magalhaes, Pedro, Dean, Olivia, Bush, Ashley I., Copolov, David L., Malhi, Gin S., Kohlmann, Kristy, Jeavons, Susan, Schapkaitz, Ian, Anderson-Hunt, Murray and Berk, Michael 2013, A preliminary investigation on the efficacy of N-acetyl cysteine for mania or hypomania, Australian and New Zealand journal of psychiatry, vol. 47, no. 6, pp. 564-568, doi: 10.1177/0004867413481631. Attached Files Name Description MIMEType Size Downloads Title A preliminary investigation on the efficacy of N-acetyl cysteine for mania or hypomania Author(s) Vieira da Silva Magalhaes, Pedro Dean, Olivia orcid.org/0000-0002-2776-3935 Bush, Ashley I. Copolov, David L. Malhi, Gin S. Kohlmann, Kristy Jeavons, Susan Schapkaitz, Ian Anderson-Hunt, Murray Berk, Michael orcid.org/0000-0002-5554-6946 Journal name Australian and New Zealand journal of psychiatry Volume number 47 Issue number 6 Start page 564 End page 568 Total pages 5 Publisher Sage Publications Place of publication London, England Publication date 2013-06 ISSN 0004-8674 1440-1614 Keyword(s) Bipolar disorder depression mania N-acetyl cysteine oxidative stress remission treatment Summary Objective: Oxidative imbalance has emerged as a treatment target in bipolar disorder. As very limited data are available on the clinical use of antioxidants for mania, we report here results from a post hoc and exploratory subgroup analysis of a randomized, placebo-controlled trial of N-acetyl cysteine (NAC). Methods: This was a placebo-controlled, randomized, clinical trial assessing the effect of NAC over 24 weeks in mania or hypomania. Symptomatic and functional outcomes were collected over the study period. Results: Fifteen participants were available for this report; two participants in each group failed to complete all assessments. Within-group analyses pointed to an improvement in the NAC group on manic symptoms and worsening in the placebo group on depressive symptoms at endpoint. Conclusions: Although the sample size was small, these results indicated within-group efficacy for this glutathione precursor as compared to placebo. Future trials specifically designed to demonstrate the efficacy of NAC in mania are needed. Language eng DOI 10.1177/0004867413481631 Field of Research 119999 Medical and Health Sciences not elsewhere classified Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1 Refereed article in a scholarly journal Grant ID NHMRC 1026307 Copyright notice ©2013, Sage Publishing Persistent URL http://hdl.handle.net/10536/DRO/DU:30052815 Document type: Journal Article Collections: Faculty of Health School of Medicine Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Tue, 04 Jun 2013, 13:34:51 EST Wed, 05 Jun 2013, 09:19:08 EST Fri, 07 Jun 2013, 11:02:49 EST Fri, 07 Jun 2013, 11:51:04 EST Tue, 16 Jul 2013, 09:45:06 EST Tue, 16 Jul 2013, 09:45:39 EST Mon, 03 Feb 2014, 15:58:39 EST Mon, 12 May 2014, 15:27:22 EST Filtered Full Citation counts:   Cited 44 times in TR Web of Science Cited 43 times in Scopus Search Google Scholar Access Statistics: 1134 Abstract Views, 3 File Downloads  -  Detailed Statistics Created: Tue, 04 Jun 2013, 13:34:38 EST by Jane Moschetti