Airway clearance of apoptotic cells in COPD

Mukaro, Violet R.S. and Hodge, Sandra 2011, Airway clearance of apoptotic cells in COPD, Current drug target, vol. 12, no. 4, pp. 460-468.

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Title Airway clearance of apoptotic cells in COPD
Author(s) Mukaro, Violet R.S.
Hodge, Sandra
Journal name Current drug target
Volume number 12
Issue number 4
Start page 460
End page 468
Total pages 10
Publisher Bentham Science Publishers
Place of publication Bussum, The Netherlands
Publication date 2011
ISSN 1389-4501
Keyword(s) Alveolar macrophage
Summary Apoptosis of bronchial epithelial cells and the phagocytic clearance of these cells by alveolar macrophages (a process termed efferocytosis) are integral processes leading to repair of airway epithelial injury. Efferocytosis allows for the removal of apoptotic material with minimal inflammation and prevents the development of secondary necrosis and ongoing inflammation. Defective efferocytosis and the increased presence of apoptotic cells have been identified in the airways of subjects with chronic obstructive pulmonary disease (COPD). There are three major potential causes for this accumulation of apoptotic cells: (i) increased apoptosis per se as a result of an increase in apoptotic mediators, (ii) defects in the recognition of apoptotic cells by AM and (iii) failure to clear the unwanted cells by the process of efferocytosis. The implications of these processes in COPD and novel treatment strategies aimed at improving clearance of apoptotic cells form the focus of the present review.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
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Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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