Immunomodulatory lactoferrin in the regulation of apoptosis modulatory proteins in cancer Kanwar, Rupinder K and Kanwar, Jagat R 2013, Immunomodulatory lactoferrin in the regulation of apoptosis modulatory proteins in cancer, Protein & peptide letters, vol. 20, no. 4, pp. 450-458, doi: 10.2174/0929866511320040009. Attached Files Name Description MIMEType Size Downloads Title Immunomodulatory lactoferrin in the regulation of apoptosis modulatory proteins in cancer Author(s) Kanwar, Rupinder K Kanwar, Jagat R orcid.org/0000-0003-3728-9568 Journal name Protein & peptide letters Volume number 20 Issue number 4 Start page 450 End page 458 Total pages 9 Publisher Bentham Science Publishers Place of publication Bussum, The Netherlands Publication date 2013 ISSN 1875-5305 0929-8665 Keyword(s) anti-apoptotic proteins immunomodulatory angiogenesis tumour growth drug resistance radioresistance anti-inflammatory Summary Lactoferrin (Lf), an iron binding ~80 kDa glycoprotein is a well characterized multifunctional protein found to be present in mammalian milk and in most exocrine secretions. Besides Lf’s important physiological roles in the process of iron homeostasis, iron transportation and sequestration, it is well known for its properties such as anti-microbial, antiviral anti-inflammatory and immunomodulatory functions. In the recent decade, Lf has gained significant attention for its future potential use as a safer natural food (bovine milk) derived anti-cancer therapeutic. With regards to Lf’s chemopreventive effects in targeting carcinogenesis, both animal and human studies have widely reported its immunomodulatory properties to play a significant role. The deregulation of apoptosis (programmed cell death) mechanisms has not only major implications for the development of uncontrolled tumour growth but evasion of apoptosis is also an important factor affecting drug resistance and radioresistance in cancer. With the exception of few studies, the molecular basis by Lf treatment remains unclear. In this review, by addressing the main features of Lf’s structure and function we discuss the recent developments in delineating the therapeutic mechanisms of Lf and its effects on the proteins and receptors modulating apoptosis. Notes ATTENTION ERA 2015 CLUSTER LEADERS: The Library does not currently have access to the research output associated with this record, please contact DRO staff for further information regarding access.drosupport@deakin.edu.au Language eng DOI 10.2174/0929866511320040009 Field of Research 060103 Cell Development, Proliferation and Death Socio Economic Objective 970106 - Expanding Knowledge in the Biological Sciences, 970111 - Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1 Refereed article in a scholarly journal Persistent URL http://hdl.handle.net/10536/DRO/DU:30054668 Document type: Journal Article Collection: Faculty of Health Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Mon, 29 Jul 2013, 18:45:27 EST Mon, 29 Jul 2013, 18:46:07 EST Tue, 30 Jul 2013, 09:03:55 EST Wed, 11 Sep 2013, 12:21:03 EST Thu, 12 Sep 2013, 09:34:34 EST Thu, 12 Sep 2013, 09:38:20 EST Thu, 18 Sep 2014, 11:25:35 EST Tue, 23 Sep 2014, 14:12:34 EST Filtered Full Citation counts:   Cited 35 times in TR Web of Science Cited 35 times in Scopus Search Google Scholar Access Statistics: 701 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Mon, 29 Jul 2013, 18:45:25 EST by Rupinder Kanwar