Impact on hemostatic parameters of interrupting sitting with intermittent activity

Howard, Bethany J, Fraser, Streve F, Sethi, Parneet, Cerin, Ester, Hamilton, Marc T, Owen, Neville, Dunstan, David W and Kingwell, Bronwyn A 2013, Impact on hemostatic parameters of interrupting sitting with intermittent activity, Medicine & science in sports & exercise, vol. 45, no. 7, pp. 1285-1291, doi: 10.1249/MSS.0b013e318285f57e.

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Title Impact on hemostatic parameters of interrupting sitting with intermittent activity
Author(s) Howard, Bethany J
Fraser, Streve FORCID iD for Fraser, Streve F
Sethi, Parneet
Cerin, Ester
Hamilton, Marc T
Owen, Neville
Dunstan, David W
Kingwell, Bronwyn A
Journal name Medicine & science in sports & exercise
Volume number 45
Issue number 7
Start page 1285
End page 1291
Total pages 7
Publisher Lippincott William & Wilkins
Place of publication Philadelphia, Pa.
Publication date 2013-07
ISSN 0195-9131
Keyword(s) Fibrinogen
Blood volume
Sedentary behavior
Physical activity
Venous thrombosis
Summary Introduction: Excessive sitting has been associated with an elevated risk of vascular conditions, particularly venous thrombosis. Interrupting sitting time with intermittent physical activity can reduce venous stasis; however, impacts on other aspects of thrombogenesis are less understood. Purpose: To examine the effects of interrupting sitting time on blood coagulation and blood volume parameters in sedentary, middle-age, overweight/obese adults (11 men and 8 women; age = 53.8 T 4.9 yr, body mass index = 31.2 T 4.1 kgImj2; mean T SD). Methods: The randomized three-period, three-treatment acute crossover trial consisted of uninterrupted sitting and sitting interrupted by 2-min bouts of either light- or moderate-intensity treadmill walking every 20 min. In each trial condition, blood samples were collected at baseline before the consumption of a standardized meal (j2 h) and postintervention (5 h). Results: Plasma fibrinogen increased from baseline with uninterrupted sitting (0.24 gILj1, 95% confidence interval = 0.13–0.34, P G 0.001). Lightintensity but not moderate-intensity activity breaks attenuated the increase by 0.17 gILj1 (95% confidence interval = 0.01–0.32, P G 0.05). There were no between-condition differences in prothrombin time, activated partial thromboplastin time, von Willebrand
factor, D-dimer, or platelet count. Uninterrupted sitting reduced plasma volume and increased hematocrit, hemoglobin, and red blood cell count; effects attenuated by both light- and moderate-intensity breaks (P G 0.05). White blood cell count increased with uninterrupted sitting and further increased with moderate-intensity breaks. Mean platelet volume increased with moderate-intensity but not lightintensity breaks or uninterrupted sitting. Conclusion: Uninterrupted sitting increased fibrinogen and reduced plasma volume, with associated increases in hemoglobin and hematocrit. Activity breaks attenuated these responses, indicative of an ameliorating influence on the procoagulant effects of uninterrupted sitting.
Language eng
DOI 10.1249/MSS.0b013e318285f57e
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 920401 Behaviour and Health
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2013, Lipincott William & Wilkins
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Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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Created: Fri, 09 Aug 2013, 15:35:45 EST by Barb Lavelle

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