Treatment response for acute depression is not associated with number of previous episodes: lack of evidence for a clinical staging model for major depressive disorder Dodd, Seetal, Berk, Michael, Kelin, Katarina, Mancini, Michele and Schacht, Alexander 2013, Treatment response for acute depression is not associated with number of previous episodes: lack of evidence for a clinical staging model for major depressive disorder, Journal of affective disorders, vol. 150, pp. 344-349, doi: 10.1016/j.jad.2013.04.016. Attached Files Name Description MIMEType Size Downloads Title Treatment response for acute depression is not associated with number of previous episodes: lack of evidence for a clinical staging model for major depressive disorder Author(s) Dodd, Seetal orcid.org/0000-0002-7918-4636 Berk, Michael orcid.org/0000-0002-5554-6946 Kelin, Katarina Mancini, Michele Schacht, Alexander Journal name Journal of affective disorders Volume number 150 Start page 344 End page 349 Total pages 6 Publisher Elsevier BV Place of publication Amsterdam, The Netherlands Publication date 2013 ISSN 0165-0327 1573-2517 Keyword(s) depression treatment staging antidepressant meta-analysis Summary Mental illness has been observed to follow a neuroprogressive course, commencing with prodrome, then onset, recurrence and finally chronic illness. In bipolar disorder and schizophrenia responsiveness to treatment mirrors these stages of illness progression, with greater response to treatment in the earlier stages of illness and greater treatment resistance in chronic late stage illness. Using data from 5627 participants in 15 controlled trials of duloxetine, comparator arm (paroxetine, venlafaxine, escitalopram) or placebo for the treatment of an acute depressive episode, the relationship between treatment response and number of previous depressive episodes was determined. Data was dichotomised for comparisons between participants who had >3 previous episodes (n=1697) or ≤3 previous episodes (n=3930), and additionally for no previous episodes (n=1381) or at least one previous episode (n=4246). Analyses were conducted by study arm for each clinical trial, and results were then pooled. There was no significant difference between treatment response and number of previous depressive episodes. This unexpected finding suggests that treatments to reduce symptoms of depression during acute illness do not lose efficacy for patients with a longer history of illness. Language eng DOI 10.1016/j.jad.2013.04.016 Field of Research 119999 Medical and Health Sciences not elsewhere classified Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article HERDC collection year 2013 Persistent URL http://hdl.handle.net/10536/DRO/DU:30055525 Document type: Journal Article Collections: Faculty of Health School of Medicine Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Fri, 30 Aug 2013, 14:09:28 EST Mon, 02 Sep 2013, 08:57:02 EST Tue, 03 Sep 2013, 12:44:49 EST Tue, 03 Sep 2013, 12:46:37 EST Tue, 03 Sep 2013, 12:47:32 EST Wed, 04 Sep 2013, 09:50:45 EST Tue, 03 Feb 2015, 13:35:37 EST Wed, 14 Oct 2015, 13:32:37 EST Wed, 18 Nov 2015, 07:35:50 EST Filtered Full Citation counts:   Cited 11 times in TR Web of Science Cited 13 times in Scopus Search Google Scholar Access Statistics: 966 Abstract Views, 3 File Downloads  -  Detailed Statistics Created: Fri, 30 Aug 2013, 14:09:14 EST by Barb Lavelle