Preoperative immunonutrition and its effect on postoperative outcomes in well-nourished and malnourished gastrointestinal surgery patients: a randomised controlled trial Barker, L. A., Gray, C., Wilson, L., Thomson, B. N. J., Shedda, S. and Crowe, T. C. 2013, Preoperative immunonutrition and its effect on postoperative outcomes in well-nourished and malnourished gastrointestinal surgery patients: a randomised controlled trial, European journal of clinical nutrition, vol. 67, pp. 802-807, doi: 10.1038/ejcn.2013.117. Attached Files Name Description MIMEType Size Downloads Title Preoperative immunonutrition and its effect on postoperative outcomes in well-nourished and malnourished gastrointestinal surgery patients: a randomised controlled trial Author(s) Barker, L. A. Gray, C. Wilson, L. Thomson, B. N. J. Shedda, S. Crowe, T. C. Journal name European journal of clinical nutrition Volume number 67 Start page 802 End page 807 Total pages 6 Publisher Nature Publishing Group Place of publication London, England Publication date 2013 ISSN 0954-3007 Keyword(s) gastrointestinal surgery malnutrition length of stay immunonutrition cost Summary Background/Objectives: Invasive procedures such as surgery cause immunosuppression, leading to increased risk of complications, infections and extended hospital stay. Emerging research around immune-enhancing nutrition supplements and their ability to reduce postoperative complications and reduce treatment costs is promising. This randomised controlled trial aims to examine the effect of preoperative immunonutrition supplementation on length of hospital stay (LOS), complications and treatment costs in both well-nourished and malnourished gastrointestinal surgery patients. Subjects/Methods: Ninety-five patients undergoing elective upper and lower gastrointestinal surgery were recruited. The treatment group (n=46) received a commercial immuno-enhancing supplement 5 days preoperatively. The control group (n=49) received no supplements. The primary outcome measure was LOS, and secondary outcome measures included complications and cost. Results: A nonsignificant trend towards a shorter LOS within the treatment group was observed (7.1±4.1 compared with 8.8±6.5 days; P=0.11). For malnourished patients, this trend was greater with hospital stay reduced by 4 days (8.3±3.5 vs 12.3±9.5 days; P=0.21). Complications and unplanned intensive care admission rates were very low in both the groups. The average admission cost was reduced by AUD1576 in the treatment group compared with the control group (P=0.37). Conclusions: Preoperative immunonutrition therapy in gastrointestinal surgery has the potential to reduce the LOS and cost, with greater treatment benefit seen in malnourished patients; however, there is a need for additional research with greater patient numbers. Language eng DOI 10.1038/ejcn.2013.117 Field of Research 111101 Clinical and Sports Nutrition Socio Economic Objective 920105 Digestive System Disorders HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2013, Nature Publishing Group Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30057086 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Open Access Collection Related Links Link Description Link to full-text (open access)   Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Tue, 22 Oct 2013, 11:35:55 EST Wed, 23 Oct 2013, 08:40:58 EST Tue, 29 Oct 2013, 14:22:29 EST Tue, 29 Oct 2013, 14:23:44 EST Wed, 30 Oct 2013, 12:29:10 EST Wed, 30 Oct 2013, 12:31:07 EST Thu, 31 Oct 2013, 08:59:17 EST Tue, 05 Nov 2013, 15:00:22 EST Tue, 08 Sep 2015, 12:42:17 EST Wed, 14 Oct 2015, 13:34:46 EST Wed, 18 Nov 2015, 07:03:01 EST Mon, 29 Mar 2021, 02:35:24 EST Filtered Full Citation counts:   Cited 32 times in TR Web of Science Cited 34 times in Scopus Search Google Scholar Access Statistics: 444 Abstract Views, 2 File Downloads  -  Detailed Statistics Created: Tue, 22 Oct 2013, 11:35:41 EST by Jane Moschetti

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.