The shared role of oxidative stress and inflammation in major depressive disorder and nicotine dependence Nunes, Sandra, Vargas, Herber, Prado, Eduardo, Barbosa, Decio, Picoli de Melo, Luiz, Moylan, Steven, Dodd, Seetal and Berk, Michael 2013, The shared role of oxidative stress and inflammation in major depressive disorder and nicotine dependence, Neuroscience and biobehavioral reviews, vol. 37, pp. 1336-1345, doi: 10.1016/j.neubiorev.2013.04.014. Attached Files Name Description MIMEType Size Downloads Title The shared role of oxidative stress and inflammation in major depressive disorder and nicotine dependence Author(s) Nunes, Sandra Vargas, Herber Prado, Eduardo Barbosa, Decio Picoli de Melo, Luiz Moylan, Steven orcid.org/0000-0001-8901-6225 Dodd, Seetal orcid.org/0000-0002-7918-4636 Berk, Michael orcid.org/0000-0002-5554-6946 Journal name Neuroscience and biobehavioral reviews Volume number 37 Start page 1336 End page 1345 Total pages 10 Publisher Elsevier Place of publication Amsterdam, The Netherlands Publication date 2013-09 ISSN 0149-7634 1873-7528 Keyword(s) dependence depression inflammation nicotine oxidative stress Summary Nicotine dependence is common in people with mood disorders; however the operative pathways are not well understood. This paper reviews the contribution of inflammation and oxidative stress pathways to the co-association of depressive disorder and nicotine dependence, including increased levels of pro-inflammatory cytokines, increased acute phase proteins, decreased levels of antioxidants and increased oxidative stress. These could be some of the potential pathophysiological mechanisms involved in neuroprogression. The shared inflammatory and oxidative stress pathways by which smoking may increase the risk for development of depressive disorders are in part mediated by increased levels of pro-inflammatory cytokines, diverse neurotransmitter systems, activation the hypothalamic-pituitary-adrenal (HPA) axis, microglial activation, increased production of oxidative stress and decreased levels of antioxidants. Depressive disorder and nicotine dependence are additionally linked imbalance between neuroprotective and neurodegenerative metabolites in the kynurenine pathway that contribute to neuroprogression. These pathways provide a mechanistic framework for understanding the interaction between nicotine dependence and depressive disorder. Language eng DOI 10.1016/j.neubiorev.2013.04.014 Field of Research 119999 Medical and Health Sciences not elsewhere classified Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1 Refereed article in a scholarly journal Grant ID NHMRC 628395 Copyright notice ©2013, Elsevier Persistent URL http://hdl.handle.net/10536/DRO/DU:30057563 Document type: Journal Article Collections: Faculty of Health School of Medicine Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Tue, 12 Nov 2013, 10:13:26 EST Wed, 13 Nov 2013, 07:23:34 EST Thu, 14 Nov 2013, 07:41:31 EST Thu, 14 Nov 2013, 07:43:16 EST Thu, 14 Nov 2013, 07:45:55 EST Thu, 14 Nov 2013, 14:12:31 EST Thu, 14 Nov 2013, 14:13:05 EST Fri, 15 Nov 2013, 13:11:26 EST Mon, 18 Nov 2013, 09:15:32 EST Mon, 18 Nov 2013, 09:16:12 EST Mon, 12 May 2014, 15:31:53 EST Fri, 13 Jun 2014, 18:42:34 EST Wed, 02 Jul 2014, 16:45:24 EST Filtered Full Citation counts:   Cited 55 times in TR Web of Science Cited 60 times in Scopus Search Google Scholar Access Statistics: 1231 Abstract Views, 5 File Downloads  -  Detailed Statistics Created: Tue, 12 Nov 2013, 10:13:08 EST by Jane Moschetti