The shared role of oxidative stress and inflammation in major depressive disorder and nicotine dependence

Nunes, Sandra, Vargas, Herber, Prado, Eduardo, Barbosa, Decio, Picoli de Melo, Luiz, Moylan, Steven, Dodd, Seetal and Berk, Michael 2013, The shared role of oxidative stress and inflammation in major depressive disorder and nicotine dependence, Neuroscience and biobehavioral reviews, vol. 37, pp. 1336-1345, doi: 10.1016/j.neubiorev.2013.04.014.

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Title The shared role of oxidative stress and inflammation in major depressive disorder and nicotine dependence
Author(s) Nunes, Sandra
Vargas, Herber
Prado, Eduardo
Barbosa, Decio
Picoli de Melo, Luiz
Moylan, Steven
Dodd, SeetalORCID iD for Dodd, Seetal
Berk, MichaelORCID iD for Berk, Michael
Journal name Neuroscience and biobehavioral reviews
Volume number 37
Start page 1336
End page 1345
Total pages 10
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2013-09
ISSN 0149-7634
Keyword(s) dependence
oxidative stress
Summary Nicotine dependence is common in people with mood disorders; however the operative pathways are not well understood. This paper reviews the contribution of inflammation and oxidative stress pathways to the co-association of depressive disorder and nicotine dependence, including increased levels of pro-inflammatory cytokines, increased acute phase proteins, decreased levels of antioxidants and increased oxidative stress. These could be some of the potential pathophysiological mechanisms involved in neuroprogression. The shared inflammatory and oxidative stress pathways by which smoking may increase the risk for development of depressive disorders are in part mediated by increased levels of pro-inflammatory cytokines, diverse neurotransmitter systems, activation the hypothalamic-pituitary-adrenal (HPA) axis, microglial activation, increased production of oxidative stress and decreased levels of antioxidants. Depressive disorder and nicotine dependence are additionally linked imbalance between neuroprotective and neurodegenerative metabolites in the kynurenine pathway that contribute to neuroprogression. These pathways provide a mechanistic framework for understanding the interaction between nicotine dependence and depressive disorder.
Language eng
DOI 10.1016/j.neubiorev.2013.04.014
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Grant ID NHMRC 628395
Copyright notice ©2013, Elsevier
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Document type: Journal Article
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