Human neuronal cells : epigenetic aspects

Kukucka, Jessica, Wyllie, Tessa, Read, Justin, Mahoney, Lauren and Suphioglu, Cenk 2013, Human neuronal cells : epigenetic aspects, Biomolecular concepts, vol. 4, no. 4, pp. 319-333, doi: 10.1515/bmc-2012-0053.

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Title Human neuronal cells : epigenetic aspects
Author(s) Kukucka, Jessica
Wyllie, Tessa
Read, JustinORCID iD for Read, Justin
Mahoney, Lauren
Suphioglu, CenkORCID iD for Suphioglu, Cenk
Journal name Biomolecular concepts
Volume number 4
Issue number 4
Start page 319
End page 333
Total pages 15
Publisher Walter de Gruyter GmbH & Co. KG
Place of publication Berlin, Germany
Publication date 2013
ISSN 1868-5021
Keyword(s) acetylation
Alzheimer's disease
gene expression
Summary Histone acetyltransferases (HATs) and histone deacetylases (HDACs) promote histone posttranslational modifications, which lead to an epigenetic alteration in gene expression. Aberrant regulation of HATs and HDACs in neuronal cells results in pathological consequences such as neurodegeneration. Alzheimer's disease is the most common neurodegenerative disease of the brain, which has devastating effects on patients and loved ones. The use of pan-HDAC inhibitors has shown great therapeutic promise in ameliorating neurodegenerative ailments. Recent evidence has emerged suggesting that certain deacetylases mediate neurotoxicity, whereas others provide neuroprotection. Therefore, the inhibition of certain isoforms to alleviate neurodegenerative manifestations has now become the focus of studies. In this review, we aimed to discuss and summarize some of the most recent and promising findings of HAT and HDAC functions in neurodegenerative diseases.
Language eng
DOI 10.1515/bmc-2012-0053
Field of Research 059999 Environmental Sciences not elsewhere classified
Socio Economic Objective 970105 Expanding Knowledge in the Environmental Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2013, Walter de Gruyter GmbH & Co. KG
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