Endurance training in Wistar rats decreases receptor sensitivity to a serotonin agonist

Dwyer, D. and Browning, J. 2000, Endurance training in Wistar rats decreases receptor sensitivity to a serotonin agonist, Acta physiologica Scandinavica, vol. 170, no. 3, pp. 211-216.

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Title Endurance training in Wistar rats decreases receptor sensitivity to a serotonin agonist
Author(s) Dwyer, D.ORCID iD for Dwyer, D. orcid.org/0000-0002-8177-7262
Browning, J.
Journal name Acta physiologica Scandinavica
Volume number 170
Issue number 3
Start page 211
End page 216
Total pages 6
Publisher Wiley-Blackwell
Place of publication Chichester, England
Publication date 2000-11
ISSN 0001-6772
Keyword(s) adaptation
central fatigue
Summary There is mounting evidence that increased brain serotonin during exercise is associated with the onset of CNS-mediated fatigue. Serotonin receptor sensitivity is likely to be an important determinant of this fatigue. Alterations in brain serotonin receptor sensitivity were examined in Wistar rats throughout 6 weeks of endurance training, running on a treadmill four times a week with two exercise tests per week to exhaustion. Receptor sensitivity was determined indirectly as the reduction in exercise time in response to a dose of a serotonin (1A) agonist, m-chlorophenylpiperazine (m-CPP). The two groups of controls were used to examine (i) the effect of the injection per se on exercise performance and (ii) changes in serotonin receptor sensitivity associated with maturation. In the test group, undrugged exercise performance significantly improved by 47% after 6 weeks of training (4518 ± 729 to 6640 ± 903 s, P=0.01). Drugged exercise performance also increased significantly from week 1 to week 6 (306 ± 69–712 ± 192 s, P = 0.04). Control group results indicated that the dose of m-CPP alone caused fatigue during exercise tests and that maturation was not responsible for any decrease in receptor sensitivity. Improved resistance to the fatiguing effects of the serotonin agonist suggests desensitization of central serotonin receptors, probably the 5-HT1A receptors. Endurance training appears to stimulate an adaptive response to the fatiguing effects of increased brain serotonin, which may enhance endurance exercise performance.
Language eng
Field of Research 110602 Exercise Physiology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2000, Wiley
Persistent URL http://hdl.handle.net/10536/DRO/DU:30058707

Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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Created: Mon, 02 Dec 2013, 13:17:17 EST by Dan Dwyer

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