Zebrafish as a genetic model in pre-clinical drug testing and screening

Gibert, Y, Trengove, M C and Ward, A C 2013, Zebrafish as a genetic model in pre-clinical drug testing and screening, Current Medicinal Chemistry, vol. 20, no. 19, pp. 2458-2466.

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Title Zebrafish as a genetic model in pre-clinical drug testing and screening
Author(s) Gibert, Y
Trengove, M C
Ward, A CORCID iD for Ward, A C orcid.org/0000-0001-7945-7975
Journal name Current Medicinal Chemistry
Volume number 20
Issue number 19
Start page 2458
End page 2466
Total pages 9
Publisher Bentham Science Publishers
Place of publication Hilversum, Netherlands
Publication date 2013
ISSN 0929-8673
Keyword(s) Zebrafish
Drug discovery
Drug testing
Large-scale screen
Chemical genetics
Pre-clinical studies
Summary The traditional drug discovery pipeline for the identification and development of compounds that selectively target specific molecules to ameliorate disease remains a major focus for medical research. However, the zebrafish is increasingly providing alternative strategies for various components of this pipeline. Zebrafish and their embryos are small, easily accessible and relatively low cost, making them applicable to high-throughput, small molecule screening. Zebrafish can also be manipulated by a range of forward and reverse genetics techniques to facilitate gene discovery and functional studies. Moreover, their physiological and developmental complexity provides accurate models of human disease to underpin mechanism of action and in vivo validation studies. Finally, several of these biological characteristics make zebrafish eminently suitable for toxicity testing, including eco-toxicology. Here we review the application of zebrafish to preclinical drug development and toxicity testing, including recent advances in mutant generation, drug screening and toxicology that serve to further enhance the capabilities of this valuable model organism in drug discovery.
Language eng
Field of Research 060103 Cell Development, Proliferation and Death
Socio Economic Objective 920106 Endocrine Organs and Diseases (excl. Diabetes)
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2013, Bentham Science Publishers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30058923

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Molecular and Medical Research
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