Synergistic antibacterial effects of theaflavin in combination with ampicillin against hospital isolates of Stenotrophomonas Maltophilia Betts, Jonathan W., Murphy, Christine, Kelly, Stephen M. and Haswell, Stephen J. 2012, Synergistic antibacterial effects of theaflavin in combination with ampicillin against hospital isolates of Stenotrophomonas Maltophilia, Journal of microbiology, biotechnology and food sciences, vol. 2, no. 3, December-January, pp. 1068-1078. Attached Files Name Description MIMEType Size Downloads haswell-synergisticantibacterial-2012.pdf Published version application/pdf 617.45KB 138 Title Synergistic antibacterial effects of theaflavin in combination with ampicillin against hospital isolates of Stenotrophomonas Maltophilia Author(s) Betts, Jonathan W. Murphy, Christine Kelly, Stephen M. Haswell, Stephen J. Journal name Journal of microbiology, biotechnology and food sciences Volume number 2 Issue number 3 Season December-January Start page 1068 End page 1078 Total pages 11 Publisher Slovak University of Agriculture in Nitra Place of publication Nitra, Slovakia Publication date 2012 ISSN 1338-5178 Keyword(s) antibacterial theaflavin polyphenol synergy checkerboard Stenotrophomonas maltophilia Summary Stenotrophomonas maltophilia is an important opportunistic nosocomial pathogen that shows intrinsic resistance to many antibiotics. This often limits treatment options and can cause lengthy hospital stays. Combination treatments are often used to combat resistance and using natural compounds such as polyphenols could give increased treatment options and even the reuse of antibiotics to which high levels of resistance have been observed. A checkerboard assay was used to determine if any synergy exists between ampicillin and the polyphenol theaflavin against 9 clinical isolates and one control isolate (NCTC 13014) of S. maltophilia. It was discovered that significant synergy (P  0.05) does exist between theaflavin and ampicillin, reducing the mean MIC of ampicillin from 12.5-22.9 µg/mL, in liquid culture, to 3.125-6.25 µg/mL. The FIC index was calculated to be 0.22-0.35 confirming synergy. From these results, significant potential for medical applications can be seen and further investigation is recommended. Language eng Field of Research 060501 Bacteriology Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences HERDC Research category C1.1 Refereed article in a scholarly journal Copyright notice ©2012, Slovak University of Agriculture in Nitra Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30063533 Document type: Journal Article Collections: Office of the Deputy Vice-Chancellor (Research) Open Access Collection Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Fri, 23 May 2014, 09:38:54 EST Fri, 23 May 2014, 11:17:00 EST Mon, 09 Jun 2014, 13:41:18 EST Tue, 06 Sep 2016, 23:46:05 EST Wed, 06 Dec 2017, 06:06:41 EST Fri, 07 Sep 2018, 17:08:35 EST Filtered Full Citation counts:   Cited 6 times in TR Web of Science Cited 0 times in Scopus Search Google Scholar Access Statistics: 443 Abstract Views, 138 File Downloads  -  Detailed Statistics Created: Fri, 23 May 2014, 09:38:54 EST