New insights into the role of MHC diversity in devil facial tumour disease Lane, Amanda, Cheng, Yuanyuan, Wright, Belinda, Hamede, Rodrigo, Levan, Laura, Jones, Menna, Ujvari, Beata and Belov, Katherine 2012, New insights into the role of MHC diversity in devil facial tumour disease, PLoS one, vol. 7, no. 6, pp. 1-9, doi: 10.1371/journal.pone.0036955. Attached Files Name Description MIMEType Size Downloads ujvari-newinsights-2012.pdf Published version application/pdf 507.60KB 190 Title New insights into the role of MHC diversity in devil facial tumour disease Author(s) Lane, Amanda Cheng, Yuanyuan Wright, Belinda Hamede, Rodrigo Levan, Laura Jones, Menna Ujvari, Beata orcid.org/0000-0003-2391-2988 Belov, Katherine Journal name PLoS one Volume number 7 Issue number 6 Start page 1 End page 9 Total pages 9 Publisher Public Library of Science Place of publication San Fransico, Calif. Publication date 2012 ISSN 1932-6203 Keyword(s) tasmanian devil tumour DFTD evolution cancer marsupial Summary Devil facial tumour disease (DFTD) is a fatal contagious cancer that has decimated Tasmanian devil populations. The tumour has spread without invoking immune responses, possibly due to low levels of Major Histocompatibility Complex (MHC) diversity in Tasmanian devils. Animals from a region in north-western Tasmania have lower infection rates than those in the east of the state. This area is a genetic transition zone between sub-populations, with individuals from north-western Tasmania displaying greater diversity than eastern devils at MHC genes, primarily through MHC class I gene copy number variation. Here we test the hypothesis that animals that remain healthy and tumour free show predictable differences at MHC loci compared to animals that develop the disease. Language eng DOI 10.1371/journal.pone.0036955 Field of Research 069999 Biological Sciences not elsewhere classified Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences HERDC Research category C1.1 Refereed article in a scholarly journal Copyright notice ©2012, Public Library of Science Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30063804 Document type: Journal Article Collections: Faculty of Science, Engineering and Built Environment Open Access Collection Centre for Integrative Ecology Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Mon, 02 Jun 2014, 10:08:26 EST Mon, 02 Jun 2014, 13:08:34 EST Thu, 12 Jun 2014, 11:59:37 EST Fri, 13 Jun 2014, 13:23:44 EST Wed, 18 Jun 2014, 08:36:28 EST Thu, 11 Dec 2014, 20:25:22 EST Wed, 18 Nov 2015, 06:47:44 EST Sat, 21 Oct 2017, 02:11:50 EST Wed, 06 Dec 2017, 06:06:58 EST Fri, 07 Sep 2018, 17:09:29 EST Filtered Full Citation counts:   Cited 25 times in TR Web of Science Cited 26 times in Scopus Search Google Scholar Access Statistics: 587 Abstract Views, 190 File Downloads  -  Detailed Statistics Created: Mon, 02 Jun 2014, 10:08:26 EST

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