A four week randomised control trial of adjunctive medroxyprogesterone and tamoxifen in women with mania

Kulkarni, Jayashri, Berk, Michael, Wang, Wei, Mu, Ling, Scarr, Elizabeth, Van Rheenen, Tamsyn E., Worsely, Roisin, Gurvich, Caroline, Gavrilidis, Emorfia, de Castella, Anthony, Fitzgerald, Paul and David, Susan R. 2014, A four week randomised control trial of adjunctive medroxyprogesterone and tamoxifen in women with mania, Psychoneuroendocrinology, vol. 43, pp. 52-61, doi: 10.1016/j.psyneuen.2014.02.004.

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Title A four week randomised control trial of adjunctive medroxyprogesterone and tamoxifen in women with mania
Author(s) Kulkarni, Jayashri
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Wang, WeiORCID iD for Wang, Wei orcid.org/0000-0003-4287-1704
Mu, Ling
Scarr, Elizabeth
Van Rheenen, Tamsyn E.
Worsely, Roisin
Gurvich, Caroline
Gavrilidis, Emorfia
de Castella, Anthony
Fitzgerald, Paul
David, Susan R.
Journal name Psychoneuroendocrinology
Volume number 43
Start page 52
End page 61
Total pages 10
Publisher Pergamon
Place of publication Oxford, England
Publication date 2014-05
ISSN 0306-4530
Keyword(s) tamoxifen
bipolar disorder
schizoaffective disorder
medroxyprogesterone acetate
Summary Emerging research has suggested that hormone treatments such as selective oestrogen receptor modulators (SERMs) or progestins may be useful in the treatment of mania. The current pilot study compared the use of the SERM tamoxifen and the progestin medroxyprogesterone acetate (MPA), as an adjunct to mood stabiliser medications, for the treatment of mania symptoms in 51 women in a 28-day double blind, placebo controlled study. The primary outcome was the change between baseline and day 28 mania scores as measured by the Clinician Administered Rating Scale for Mania (CARS-M). Adjunctive MPA treatment provided greater and more rapid improvement in mania symptoms compared with adjunctive placebo and tamoxifen treatment. Adjunctive therapy with MPA may be a potentially useful new treatment for persistent mania, leading to a greater and more rapid resolution of symptoms compared with mood stabiliser treatment alone.
Language eng
DOI 10.1016/j.psyneuen.2014.02.004
Field of Research 110399 Clinical Sciences not elsewhere classified
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2014, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30065229

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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